Valve analytical system

• US 8,178,352 B2
• Filed: 06/16/2011
• Issued: 05/15/2012
• Est. Priority Date: 09/23/2009
• Status: Active Grant

• Current Assignee: Ecolab USA Incorporated (Ecolab, Inc.)
• Original Assignee: Ecolab USA Incorporated (Ecolab, Inc.)
• Inventors: Tokhtuev, Eugene, Owen, Christopher, Christensen, William
• Primary Examiner(s): Nagpaul, Jyoti
• Application Number:
  US13/162,052
• Publication Number:
  US 20110244579A1
• Time in Patent Office: 334 Days
• Field of Search: 422500-502, 422 63- 65, 436/45, 436/180, 251/142
• US Class Current: 436/45
• CPC Class Codes: B01L 3/502 with fluid transport, e.g. in multi-compartment structures centrifugal-type cuvettes G01N21/07; analysis by separation into components G01N30/00; automatic analysers G01N35/00
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: G01N 35/1097 characterised by the valves valves in general F16K
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/111666 Utilizing a centrifuge or compartmented rotor
• CPC Class Codes: Y10T 436/15 Inorganic acid or base [e.g. , hcl, sulfuric acid, etc. ]
• CPC Class Codes: Y10T 436/201666 Carboxylic acid
• CPC Class Codes: Y10T 436/206664 Ozone or peroxide
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

A lab on a valve analytical system includes a rotary sample preparation assembly having a stator and a rotor. The rotor includes a plurality of integral syringe pumps which can be aligned with passages formed within the stator. The stator passages can be connected with fluid inlet connector which connect the sample preparation assembly with fluid sources, and fluid outlet connectors which connect the sample preparation assembly with one or more wet chemical analytical devices. Some embodiments can include a mixer and optical sensor connected with the fluid outlets. One or more drive motors can be used to control simultaneous actuation of one or more of the syringe pumps, thereby providing for simultaneous delivery of metered volumes of fluid.

Claims

1. A method for analyzing one or more characteristics of a use composition, the method comprising:

providing a rotary valve analytical system comprising;

a rotor having a rotor face, the rotor being rotatable about an axis perpendicular to the rotor face, wherein the rotor face has a plurality of openings, each of which extends into the rotor to form syringe barrels;

a stator disposed coaxially with the rotor, the stator having a stator face in sealable, slidable, rotary contact with the rotor face, wherein the stator comprises a plurality of inlet passages and outlet passages passing therethrough, each inlet passage providing for fluid communication between a fluid source and an opening within the stator face, and each outlet passage providing for fluid communication between an opening within the stator face and a mixer line, wherein one or more of the fluid sources comprises a source of the use composition;

a mixer having a plurality of inputs each in fluid communication with one of the mixer lines and an output in fluid communication with a sensor line; and

a sensor coupled with the sensor line;

rotating the rotor to a first position, such that the syringe barrels within the rotor are aligned with one or more of the inlet passages within the stator and the other openings within the stator face are sealed by the rotor face, wherein one or more of the aligned inlet passages are in fluid communication with the source of the use composition;

drawing fluid into each of the syringe barrels from the aligned inlet passages;

rotating the rotor to a second position, such that each of the syringe barrels are aligned with one of the outlet passages and the other openings within the stator face are sealed by the rotor face;

driving fluid from the syringe barrels and through the aligned fluid outlet passages into the mixer lines;

mixing the fluids in the mixer resulting in a sample mixture within the sensor line;

measuring one or more properties of the sample mixture with the sensor, the properties being indicative of the one or more characteristics of the use composition; and

determining the one or more characteristics of the use composition from the measurement.

2. The method of claim 1, further comprising disposing of the sample mixture after measuring one or more properties of the sample mixture.

3. The method of claim 1, wherein drawing fluid into each of the syringe barrels comprises drawing the use composition into a first syringe barrel, drawing a reagent into a second syringe barrel, and drawing an acid into a third syringe barrel.

4. The method of claim 3, wherein drawing fluid into each of the syringe barrels further comprises drawing a diluent into a fourth syringe barrel.

5. The method of claim 3, wherein the reagent comprises potassium iodide, and the acid comprises acetic acid.

6. The method of claim 1, further comprising performing a calibration cycle, the calibration cycle comprising:

rotating the rotor to a third position, such that the syringe barrels within the rotor are aligned with one or more of the inlet passages within the stator and the other openings within the stator face are sealed by the rotor face, wherein none of the aligned inlet passages are in fluid communication with the source of the use composition;

drawing fluid into each of the syringe barrels from the aligned inlet passages;

rotating the rotor to the second position, such that each of the syringe barrels are aligned with one of the outlet passages and the other openings within the stator face are sealed by the rotor face;

driving fluid from the syringe barrels and through the aligned fluid outlet passages into the mixer lines;

mixing the fluids in the mixer to produce a blank mixture within the sensor line;

measuring one or more calibration properties of the blank mixture with the sensor; and

storing the calibration properties such that the calibration properties can be used during the determination of the one or more characteristics of the use composition.

7. The method of claim 6, wherein drawing fluid into each of the syringe barrels during the calibration cycle comprises drawing water into a first syringe barrel, drawing a reagent into a second syringe barrel, and drawing an acid into a third syringe barrel.

8. The method of claim 1, wherein the sensor comprises an optical sensor, and the one or more properties of the sample mixture comprise one or more optical properties thereof.

9. The method of claim 8, wherein the one or more optical properties comprise at least one of transmittance, absorbance, fluorescence, and a time or a temperature derivative thereof.

10. The method of claim 8, wherein the one or more optical properties comprise absorbance and a time derivative of absorbance.

11. The method of claim 1, wherein the one or more characteristics of the use composition comprises the concentration of one or more analytes within the use composition.

12. The method of claim 11, wherein the one or more analytes comprise a peracid and a peroxide.

13. The method of claim 1, wherein from 10 μ

l to 100 μ

l of fluid are drawn into and driven from the syringe barrels.

14. The method of claim 13, wherein 30 μ

l of fluid are drawn into and driven from the syringe barrels.

15. The method of claim 1, wherein rotating the rotor to the first position and rotating the rotor to the second position each comprise actuating a rotor drive motor to rotate the rotor.

16. The method of claim 1, wherein rotating the rotor to the second position comprises rotating the rotor while fluid drawn into each of the syringe barrels is held in each of the syringe barrels.

17. The method of claim 1, wherein the rotor defines a rotor face, and the stator defines a stator face, and rotating the rotor to the first position and rotating the rotor to the second position each comprise sliding the rotor face over the stator face while maintaining a fluid seal such that fluid cannot seep between the rotor face and the stator face.

18. A lab on a valve analytical system for determining a concentration of a peracid and a peroxide within a use composition, comprising:

a valve assembly, comprising;

a rotor having a rotor face and a plurality of syringe barrels extending into the rotor from openings in the rotor face, the rotor being rotatable about an axis perpendicular to the rotor face,

a stator disposed coaxially with the rotor, the stator having a stator face in sealable, slidable, rotary contact with the rotor face and a plurality of groups of passages, each group of passages comprising a plurality of passages each of which extends through the stator from an opening on the stator face to a connector port, wherein each passage of the groups of passages is disposed at a common radial distance from the axis such that each group of passages can be aligned with at least one syringe barrel by rotating the rotor relative to the stator, and

a plurality of syringe plungers, one of said syringe plungers disposed in each of the syringe barrels, each syringe plunger adapted to draw fluid into and drive fluid from the syringe barrel in which it is disposed,

wherein one or more of the connector ports is in fluid communication with a source of the use composition, one or more of the connector ports is in fluid communication with a source of a reagent, and one or more of the connector ports is in fluid communication with a source of an acid;

a mixer, in fluid communication with the connector port of one of the passages of each group of passages of the stator, the mixer adapted to produce a sample mixture comprising quantities of the use composition, the reagent, and the acid; and

a sensor in fluid communication with the mixer, the sensor adapted to measure one or more properties of the sample mixture indicative of the concentration of the peracid and the concentration of the peroxide within the use composition.

19. The lab on a valve analytical system of claim 18, wherein the reagent comprises potassium iodide.

20. The lab on a valve analytical system of claim 18, wherein the acid comprises acetic acid.