Modified human growth hormone formulations with an increased serum half-life
First Claim
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1. A pharmaceutical formulation of human growth hormone (hGH) polypeptide comprising a non-naturally encoded amino acid wherein the non-naturally encoded amino acid is substituted at a position corresponding to a position selected from the group 35, 92, 131, 134, 143, and 145 of SEQ ID NO:
- 2 and wherein the non-naturally encoded amino acid is linked to a linear polyethylene glycol through an oxime bond and wherein the polyethylene glycol has a molecular weight of at least 20 kDa-40 kDa, wherein said formulation is liquid, and wherein the serum half-life of the PEGylated hGH is at least two-fold greater than the serum half-life of a naturally occurring, unPEGylated version of an hGH protein.
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Abstract
Formulations of modified growth hormone polypeptides are provided, including human growth hormone polypeptides with one or more non-naturally encoded amino acids with an increased half-life.
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3 Claims
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1. A pharmaceutical formulation of human growth hormone (hGH) polypeptide comprising a non-naturally encoded amino acid wherein the non-naturally encoded amino acid is substituted at a position corresponding to a position selected from the group 35, 92, 131, 134, 143, and 145 of SEQ ID NO:
- 2 and wherein the non-naturally encoded amino acid is linked to a linear polyethylene glycol through an oxime bond and wherein the polyethylene glycol has a molecular weight of at least 20 kDa-40 kDa, wherein said formulation is liquid, and wherein the serum half-life of the PEGylated hGH is at least two-fold greater than the serum half-life of a naturally occurring, unPEGylated version of an hGH protein.
- View Dependent Claims (2)
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3. A pharmaceutical formulation of human growth hormone (hGH) polypeptide comprising a non-naturally encoded amino acid wherein the non-naturally encoded amino acid is substituted at a position corresponding to a position selected from the group 35, 92, 131, 134, 143, and 145 of SEQ ID NO:
- 2 and wherein the non-naturally encoded amino acid is linked to a linear polyethylene glycol through an oxime bond and wherein the polyethylene glycol has a molecular weight of at least 20 kDa-40 kDa and wherein the serum half-life of the PEGylated hGH is at least two-fold greater than the serum half-life of a naturally occurring, unPEGylated hGH protein and wherein said formulation is lyophilized.
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