Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
First Claim
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1. A method of modulating the level of a precursor miRNA comprising:
- contacting a cell with an oligomeric compound consisting of 15 to 30 monomeric subunits;
wherein the oligomeric compound is complementary to the precursor miRNA and at least one monomeric subunit is a modified nucleoside or a nucleoside mimetic; and
thereby modulating the level of the precursor miRNA.
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Abstract
Compounds, compositions and methods are provided for modulating the expression and function of small non-coding RNAs. The compositions comprise oligomeric compounds, targeted to small non-coding RNAs. Methods of using these compounds for modulation of small non-coding RNAs as well as downstream targets of these RNAs and for diagnosis and treatment of disease associated with small non-coding RNAs are also provided.
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Citations
21 Claims
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1. A method of modulating the level of a precursor miRNA comprising:
contacting a cell with an oligomeric compound consisting of 15 to 30 monomeric subunits;
wherein the oligomeric compound is complementary to the precursor miRNA and at least one monomeric subunit is a modified nucleoside or a nucleoside mimetic; and
thereby modulating the level of the precursor miRNA.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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