Method and system for cyclical neural modulation based on activity state
First Claim
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1. A method of modulating neural activity comprising:
- applying a blocking stimulus sufficient to produce a reversible conduction block of at least a portion of a peripheral neural structure of a subject with a cyclical application pattern, a cycle of the cyclical application pattern including;
a blocking period during which the blocking stimulus sufficient to produce a reversible conduction block of at least a portion of the peripheral neural structure of the subject is applied at least intermittently, the blocking period coinciding at least in part with a low activity state in the subject; and
a release period during which no blocking stimulus is applied, the release period coinciding at least in part with a higher activity state in the subject.
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Abstract
Methods and related systems for modulating neural activity by repetitively or cyclically blocking conduction in a peripheral neural structure are disclosed. Timing of delivery of blocking stimuli may be based upon overall activity level of the subject or use/activity of a portion of the body of a subject.
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Citations
53 Claims
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1. A method of modulating neural activity comprising:
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applying a blocking stimulus sufficient to produce a reversible conduction block of at least a portion of a peripheral neural structure of a subject with a cyclical application pattern, a cycle of the cyclical application pattern including; a blocking period during which the blocking stimulus sufficient to produce a reversible conduction block of at least a portion of the peripheral neural structure of the subject is applied at least intermittently, the blocking period coinciding at least in part with a low activity state in the subject; and a release period during which no blocking stimulus is applied, the release period coinciding at least in part with a higher activity state in the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A neural modulation system comprising:
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a sensor configured to generate a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure, responsive to an activity of the at least a portion of the body of the subject;
a signal input structure operatively connected to the sensor and configured to receive the signal indicative of the activity state of at least the portion of the body of the subject innervated by the peripheral neural structure;and a signal processing portion configured to; distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure, at least partially based on the signal received by the signal input structure; and generate a blocking stimulus control signal for driving production of a blocking stimulus configured to reversibly block conduction of action potentials in the peripheral neural structure of the subject during at least a portion of the low activity state. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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33. A neural modulation system comprising:
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a signal input structure configured to receive a signal indicative of an activity state of at least a portion of a body of a subject innervated by a peripheral neural structure; a user input device operatively connected to the signal input structure and configured to generate a signal responsive to a user input indicative of an activity state of at least a portion of a body of a subject innervated by the peripheral neural structure; and a signal processing portion configured to; distinguish a low activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from a higher activity state of the at least a portion of the body of the subject innervated by the peripheral neural structure from the signal received at the signal input structure; and generate a blocking stimulus configured to reversibly block conduction in the peripheral neural structure of the subject during at least a portion of the low activity state. - View Dependent Claims (34)
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35. A system comprising:
- a computer-readable medium bearing;
one or more instructions related to producing a reversible conduction block in a peripheral neural structure of at least a portion of a body of a subject while the at least a portion of a body of a subject is in a low activity state; one or more instructions related to reversing the reversible conduction block in the peripheral neural structure of the at least a portion of a body of a subject to permit conduction in the peripheral neural structure when the at least a portion of the body of the subject is in a higher activity state; and
one or more instructions related to repeating the steps of producing a reversible conduction block in the peripheral neural structure of the at least a portion of the body of the subject while the at least a portion of the body of the subject is in a low activity state and reversing the reversible conduction block in the peripheral neural structure of the at least a portion of a body of a subject to permit conduction in the peripheral neural structure when the at least a portion of the body of the subject is in a higher activity state. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
- a computer-readable medium bearing;
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46. A system comprising:
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a computer-readable medium bearing; one or more instructions related to applying a blocking stimulus sufficient to produce a reversible conduction block of at least a portion of a peripheral neural structure of a subject with a cyclical application pattern, a cycle of the cyclical application pattern including;
a blocking period during which the blocking stimulus sufficient produce a reversible conduction block of at least a portion of the peripheral neural structure of the subject is applied at least intermittently, the blocking period coinciding at least in part with a low activity state in the subject; anda release period during which no blocking stimulus is applied, the release period coinciding at least in part with a higher activity state in the subject. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53)
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Specification