Delivery of agents such as cells to tissue
First Claim
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1. A nonimplantable system for delivering a fluid comprising cells to tissue of a patient, comprising:
- at least a first container for holding an injection fluid in which an agent is carried;
a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container;
a control system in operative connection with the first powered drive and operative to control the first powered drive;
a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient;
a sensor system; and
a communication system in connection with at least the control system and the sensor system, the communication system being adapted to provide information to the control system, the control system being adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system, wherein the sensor system provides a measurement indicative of at least shear forces on the cells.
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Abstract
A system for delivering a fluid comprising cells to tissue of a patient includes a container holding an injection fluid and a powered drive. A sensor system provides a measurement indicative of at least shear forces on the cells to a control system. Based at least in part on this measurement, the control system is adapted to transmit a control signal to the powered drive for pressurizing the contents of the container to deposit cells within the tissue of a patient via a fluid path and a patient interface. As an example, the cells can be pregenitor or stem cells.
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Citations
23 Claims
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1. A nonimplantable system for delivering a fluid comprising cells to tissue of a patient, comprising:
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at least a first container for holding an injection fluid in which an agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system, the communication system being adapted to provide information to the control system, the control system being adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system, wherein the sensor system provides a measurement indicative of at least shear forces on the cells. - View Dependent Claims (2, 3)
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4. A nonimplantable system for delivering a fluid including cells to tissue of a patient, comprising:
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at least a first container for holding an injection fluid in which the cells are carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system comprising at least one cell sensor system to measure one or more properties indicative of the health of the cells and shear forces on the cells; and a communication system in connection with at least the control system and the sensor system, the sensor system being adapted to provide information to the control system, the control system being adapted to transmit a control signal to the first powered drive based at least in part on information provided to the control system. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. A nonimplantable system for delivering a fluid including an agent to tissue of a patient, comprising:
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at least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit cells within tissue of the patient; a sensor system comprising at least one tissue sensor system to measure a property of the tissue at a delivery site and at least one fluid sensor system to measure a property of the fluid to be delivered; and a communication system in connection with at least the control system and the sensor system, the sensor system being adapted to provide information to the control system, the control system being adapted to transmit a control signal to the first powered drive based at least in part on information provided to the control system, wherein the sensor system provides a measurement indicative of at least shear forces on the cells.
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Specification