Kit for parenteral administration of medicaments

• US 8,182,449 B2
• Filed: 09/29/2006
• Issued: 05/22/2012
• Est. Priority Date: 09/29/2005
• Status: Expired due to Fees

• Current Assignee: INFA SA (Aluar Aluminio Argentino S.A.I. Y C.)
• Original Assignee: INFA SA (Aluar Aluminio Argentino S.A.I. Y C.)
• Inventors: Villani, Flavio, Magri′, Paolo
• Primary Examiner(s): Sirmons, Kevin C
• Assistant Examiner(s): THOMAS, JR, BRADLEY G
• Application Number:
  US11/992,405
• Publication Number:
  US 20090264830A1
• Time in Patent Office: 2,062 Days
• Field of Search: 604/187, 604/191, 604/264, 604/416, 604/413, 604/403, 549/510, 424/465
• US Class Current: 604/187
• CPC Class Codes: A61K 31/337 having four-membered rings, e.g. taxol
• CPC Class Codes: A61K 31/436 the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
• CPC Class Codes: A61K 38/13 Cyclosporins
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61P 37/02 Immunomodulators

Abstract

The invention relates to a kit for parenteral administration of drugs, particularly a kit for the infusion of those medicaments dissolved in solvents that extract toxic components from PVC, which is also suitable for the infusion of highly active medicaments, said kit ensuring a safe administration both for the patient and for healthcare staff.

Claims

1. A pharmaceutical package comprising a kit for parenteral intravenous infusion of drugs formulated in lipophilic solvents, the kit comprising:

a) at least one vessel containing a solution for intravenous infusion that is selected from a saline and a glucose solution; and

b) a pre-filled syringe containing a solution of 1 ml of a 5 mg solution of anhydrous tacrolimus and 200 mg hydrogenated polyoxyethylenated castor oil (HCO-60) in dehydrated alcohol (USP 80% v/v), said pre-filled syringe comprising means for delivering the solution to said at least one vessel;

the vessel (a), and pre-filled syringe being made of materials compatible with lipophilic solvents.

2. The pharmaceutical package according to claim 1, characterized in that said materials compatible with lipophilic solvents are other than conventional PVC.

3. The pharmaceutical package according to claim 1, characterized in that said materials compatible with lipophilic solvents are selected from glass, polyethylene, polypropylene and PVC free of any phthalates that may be released in lipophilic solvents.

4. The pharmaceutical package according to claim 1, characterized in that said vessel (a), and pre-filled syringe (b) are made of either the same or different materials.

5. The pharmaceutical package according to claim 1, characterized in that said vessel (a) also comprises optional connectors, cannulae, flow regulators, filters and/or dosers.

6. The pharmaceutical package according to claim 1, characterized in that it comprises two vessels (a).

7. The pharmaceutical package according to claim 1, further comprising disposable gloves and an information leaflet.