Implantable prosthesis

• US 8,182,545 B2
• Filed: 07/10/2008
• Issued: 05/22/2012
• Est. Priority Date: 09/14/2000
• Status: Expired due to Term

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Cherok, Dennis, Darois, Roger E., Greene, Ronald L., Capuzziello, Thomas J., Mello, James D.
• Primary Examiner(s): Matthews, William H.
• Application Number:
  US12/171,058
• Publication Number:
  US 20080269896A1
• Time in Patent Office: 1,412 Days
• Field of Search: 623/7, 623/8, 623/11.11, 623/14.13, 623/23.71, 623/23.72, 606/151, 600/37
• US Class Current: 623/23.72
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61F 2002/009 for hindering or preventing attachment of biological tissue

Abstract

An implantable prosthesis and a method of repairing an anatomical defect, such as a tissue or muscle wall defect, by promoting tissue growth thereto, while limiting the incidence of postoperative adhesions between a portion of the prosthesis and tissue or organs. The prosthesis is formed of a biologically compatible, flexible layer of repair fabric suitable for reinforcing tissue or muscle and closing anatomical defects, and a barrier layer for physically isolating at least a portion of one side of the fabric from areas likely to form adhesions. A peripheral barrier extends about at least a portion of the outer peripheral edge of the repair fabric to inhibit adhesions between the outer peripheral edge and adjacent tissue and organs. The repair fabric may include an outer margin that has been melted and resolidified to render the outer peripheral edge substantially impervious to tissue ingrowth. The barrier layer may be joined to the repair fabric with connecting stitches formed from PTFE to inhibit the formation of adhesions thereto.

Claims

1. An implantable prosthesis for repairing a tissue or muscle wall defect, the implantable prosthesis comprising:

a layer of repair fabric that is susceptible to tissue ingrowth and the formation of adhesions with tissue and organs, the layer of repair fabric including a first surface, a second surface opposite the first surface and an outer peripheral edge with a thickness extending from the first surface to the second surface;

a barrier layer formed of a material that is substantially free of tissue infiltratable interstices to inhibit tissue ingrowth and the formation of adhesions with tissue and organs thereto, the barrier layer extending across at least a portion of the first surface to inhibit tissue ingrowth and the formation of adhesions between the portion of the first surface and adjacent tissue and organs; and

a peripheral barrier formed of a material that is substantially free of tissue infiltratable interstices to inhibit tissue ingrowth and the formation of adhesions with tissue and organs thereto, the peripheral barrier including a section of the barrier layer extending about at least a portion of the outer peripheral edge of the layer of repair fabric and over a portion of the second surface of the layer of repair fabric adjacent the outer peripheral edge, the peripheral barrier being fixedly maintained across the entire thickness of the portion of the outer peripheral edge and the portion of the second surface to inhibit tissue ingrowth and the formation of adhesions between the portion of the outer peripheral edge of the layer of repair fabric and adjacent tissue and organs.

2. The implantable prosthesis according to claim 1, wherein the layer of repair fabric includes a plurality of interstices that are constructed and arranged to allow tissue ingrowth thereto.

3. The implantable prosthesis according to claim 1, wherein the section of the barrier layer extending over the portion of the second surface includes a plurality of fluid drainage apertures adjacent the outer peripheral edge.

4. The implantable prosthesis according to claim 3, wherein the plurality of fluid drainage apertures include a plurality of slits extending inwardly away from the outer peripheral edge.

5. The implantable prosthesis according to claim 4, wherein each of the plurality of slits has a generally V-shape.

6. The implantable prosthesis according to claim 3, wherein the plurality of fluid drainage apertures are spaced inwardly away from the outer peripheral edge.

7. The implantable prosthesis according to claim 1, wherein the layer of repair fabric includes an outer perimeter, the peripheral barrier extending along the entire outer perimeter.

8. The implantable prosthesis according to claim 7, wherein the barrier layer covers the entire first surface of the layer of repair fabric.

9. The implantable prosthesis according to claim 1, wherein the layer of repair fabric and the barrier layer are connected by at least one series of stitches.

10. The implantable prosthesis according to claim 9, wherein the series of stitches are disposed slightly inward of the outer peripheral edge.

11. The implantable prosthesis according to claim 9, wherein the series of stitches are formed from an adhesion resistant material.

12. The implantable prosthesis according to claim 11, wherein the adhesion resistant material includes PTFE.

13. The implantable prosthesis according to claim 1, wherein the layer of repair fabric includes a polypropylene mesh.

14. The implantable prosthesis according to claim 13, wherein the barrier layer includes ePTFE.