Drain and fill logic for automated peritoneal dialysis

• US 8,182,673 B2
• Filed: 01/29/2009
• Issued: 05/22/2012
• Est. Priority Date: 01/29/2009
• Status: Active Grant

• Current Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Original Assignee: Baxter Healthcare SA (Baxter International Inc.), Baxter International Inc.
• Inventors: Childers, Robert W., Lo, Ying-Cheng, Hopping, Peter A.
• Primary Examiner(s): DRODGE, JOSEPH W
• Application Number:
  US12/362,259
• Publication Number:
  US 20100191181A1
• Time in Patent Office: 1,209 Days
• Field of Search: 210/96.1, 210/96.2, 210/141, 210/143, 210/321.65, 210/637, 210645-647, 210/739, 210/929, 210/85, 210/87, 604/5.01, 604/6.01, 604/6.05, 604/6.09, 604/29, 604 65- 67, 600/300, 702/19, 700/273, 705/2, 705/3, 706 45- 48, 706/61, 706/924
• US Class Current: 210/141
• CPC Class Codes: A61M 1/1522 the interface being evacuated interfaces to enhance contact
• CPC Class Codes: A61M 1/1524 the interface providing means for actuating on functional elements of the cassette, e.g. plungers
• CPC Class Codes: A61M 1/155 with treatment-fluid pumping means or components thereof
• CPC Class Codes: A61M 1/1561 at least one cassette surface or portion thereof being flexible, e.g. the cassette having a rigid base portion with preformed channels and being covered with a foil
• CPC Class Codes: A61M 1/1565 Details of valves
• CPC Class Codes: A61M 1/159 specially adapted for peritoneal dialysis
• CPC Class Codes: A61M 1/28 Peritoneal dialysis ; Other peritoneal treatment, e.g. oxygenation
• CPC Class Codes: A61M 1/281 Instillation other than by gravity
• CPC Class Codes: A61M 1/282 Operational modes
• CPC Class Codes: A61M 1/284 Continuous flow peritoneal dialysis [CFPD]
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3379 Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: B01D 61/30 Accessories; Auxiliary operation
• CPC Class Codes: B01D 61/32 Controlling or regulating

Abstract

A system and method for automatically adjusting a Continuous Cycling Peritoneal Dialysis (“CCPD”) therapy to minimize the potential for excess intra-peritoneal volume. The adjustments are made at the end of the drain, just prior to the next fill. The adjustments short the next fill, if necessary, to limit the intra-peritoneal volume, add a cycle, if necessary, to use all of the available dialysis solution and will average the remaining dwell time to maximize the therapeutic benefit of the therapy in the allotted time. In another embodiment, a tidal therapy using trended patient UF data is provided.

Claims

1. An automated peritoneal dialysis system comprising:

at least one dialysis fluid pump configured to pump a dialysis fluid to and from a patient'"'"'s peritoneal cavity during a multi-cycle dialysis therapy, the multi-cycle dialysis therapy including a plurality of patient fills, dwells, and drains;

at least one processor; and

at least one memory device storing a plurality of instructions executed by the at least one processor during the multi-cycle dialysis therapy to;

(i) control the dialysis fluid pumped by the at least one dialysis fluid pump to and from the patient'"'"'s peritoneal cavity, (ii) calculate cumulative ultrafiltration, and (iii) reduce a prescribed fill volume if an amount of a prior incomplete one of the plurality of drains from the patient'"'"'s peritoneal cavity causes the cumulative ultrafiltration at an end of the prior incomplete drain from the patient'"'"'s peritoneal cavity to exceed a negative ultrafiltration limit.

2. The dialysis system of claim 1, wherein the cumulative ultrafiltration is defined as cumulative volume drained less cumulative volume filled and does not include an initial drain and a last (wet day) fill.

3. The dialysis system of claim 1, wherein the at least one processor/memory device is configured to lessen a prescribed fill volume if a residual volume of fluid in the patient will exceed a total volume of fluid allowed within the patient.

4. The dialysis system of claim 3, wherein a predicted total volume of fluid within the patient after the prescribed fill volume has been administered includes an expected amount of ultrafiltration.

5. The dialysis system of claim 1, wherein the prescribed fill volume is reduced by at least fifteen percent.

6. The dialysis system of claim 1, wherein the prescribed fill volume is reduced to a degree that is based upon a total amount of fresh dialysis fluid remaining to be delivered to the patient divided by a total number of remaining patient fills, the total number of remaining patient fills including at least one patient fill added to a previously prescribed number of patient fills.

7. The dialysis system of claim 6, wherein the total amount of fresh dialysis fluid remaining to be delivered does not include a last fluid volume and the total number of remaining patient fills does not include a last patient fill.

8. The dialysis system of claim 1, wherein the at least one processor/memory device is further configured to add at least one patient fill in an attempt to maintain a total prescribed amount of fresh fluid delivered to the patient during the therapy.

9. The dialysis system of claim 8, wherein at least one processor/memory device is configured to reduce each remaining prescribed fill volume by a same amount.

10. The dialysis system of claim 8, wherein the at least one processor/memory device is configured to reduce each remaining prescribed fill volume by a same amount, but wherein a last prescribed fill volume is not reduced.

11. The dialysis system of claim 1, wherein the at least one processor/memory device is further configured to determine a number of remaining patient fills by dividing a total remaining therapy volume by a prescribed fill volume.

12. The dialysis system of claim 11, wherein the total remaining therapy volume does not include a last fill volume and the number of remaining patient fills does not include a last fill.

13. The dialysis system of claim 11, wherein the at least one processor/memory device is further configured to round up the number of remaining patient fills if a calculated fractional number of patient fills exceeds a threshold.

14. The dialysis system of claim 13, wherein the threshold is less than 0.5.

15. The dialysis system of claim 13, wherein the at least one processor/memory device is further configured to change a subsequent prescribed fill volume to (i) a higher fill volume equal to the total remaining therapy volume divided by a rounded down number of remaining patient fills or (ii) a lower fill volume equal to the total remaining therapy volume divided by a rounded up number of remaining patient fills.

16. The dialysis system of claim 15, wherein the at least one processor/memory device is further configured to compare the higher fill volume to the prescribed fill volume and (i) use the higher fill volume if it is within a specified ratio of the prescribed fill volume or (ii) use the lower fill volume if the higher fill volume is not within the specified ratio of the prescribed fill volume.

17. An automated peritoneal dialysis system comprising:

at least one dialysis fluid pump configured to pump a dialysis fluid to and from a patient'"'"'s peritoneal cavity during a multi-cycle dialysis therapy, the multi-cycle dialysis therapy including a plurality of patient fills, dwells, and drains;

at least one processor; and

at least one memory device storing a plurality of instructions executed by the at least one processor during the multi-cycle dialysis therapy to;

(i) control the at least one dialysis fluid pump, (ii) calculate cumulative drain volume and cumulative fill volume to determine a number of remaining cycles by dividing a total remaining therapy volume by a calculated fill volume, wherein the calculated fill volume is higher or lower than a prescribed fill volume, in order to use substantially all of a prescribed therapy volume, and (iii) if the determined number of remaining cycles is greater than zero, initiate at least one of the determined number of remaining cycles.

18. The dialysis system of claim 17, wherein the total remaining therapy volume does not include a last fill volume and the number of remaining cycles does not include a last fill.

19. The dialysis system of claim 17, wherein the at least one processor/memory device is further configured to round up the number of remaining cycles if a calculated fractional number of remaining cycles exceeds a threshold.

20. The dialysis system of claim 19, wherein at least one processor/memory device is further configured to change the prescribed fill volume to (i) a higher fill volume equal to the total remaining therapy volume divided by a rounded down number of remaining cycles or (ii) a lower fill volume equal to the total remaining therapy volume divided by a rounded up number of remaining cycles.

21. The dialysis system of claim 20, wherein at least one processor/memory device is further configured to compare the higher fill volume to the prescribed fill volume and (i) use the higher fill volume if it is within a specified ratio of the prescribed fill volume or (ii) use the lower fill volume if the higher fill volume is not within the specified ratio of the prescribed fill volume.

22. The dialysis system of claim 20, wherein the at least one processor/memory device is configured to redetermine the number of remaining cycles by dividing the total remaining therapy volume by the higher or lower fill volumes used.

23. An automated peritoneal dialysis system comprising:

at least one dialysis fluid pump configured to pump a dialysis fluid to and from a patient'"'"'s peritoneal cavity during a multi-cycle dialysis therapy, the multi-cycle dialysis therapy including a plurality of patient fills, dwells, and drains;

at least one processor; and

at least one memory device storing a plurality of instructions executed by the at least one processor during the multi-cycle dialysis therapy to;

(i) control the at least one dialysis fluid pump, (ii) calculate cumulative drain volume and cumulative fill volume to determine a number of remaining cycles by (a) adding one plus (a total remaining therapy volume divided by a prescribed fill volume) if a prior one of the plurality of drains was complete or (b) dividing the total remaining therapy volume by (the prescribed fill volume multiplied by a prescribed tidal percent) if the prior one of the plurality of drains was incomplete, wherein if the determined number of remaining cycles is greater than zero, initiate at least one of the determined number of remaining cycles, and if a cycle is added, to calculate a new fill volume by dividing the total remaining therapy volume by the number of remaining cycles.

24. The dialysis system of claim 23, wherein the total remaining therapy volume does not include a last fill volume and the number of remaining cycles does not include a last fill.

25. The dialysis system of claim 23, wherein the at least one processor/memory device is further configured to add a cycle if the total remaining therapy volume divided by the number of remaining cycles exceeds a fractional threshold.

26. The dialysis system of claim 23, wherein the at least one processor/memory device is further configured to add a cycle if the total remaining therapy volume divided by the number of remaining cycles exceeds a fractional threshold of 0.85.