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Recombinantly modified plasmin

  • US 8,182,808 B2
  • Filed: 11/22/2011
  • Issued: 05/22/2012
  • Est. Priority Date: 11/29/2007
  • Status: Active Grant
First Claim
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1. A polypeptide comprising:

  • (a) a single N-terminal kringle domain wherein the last four amino acid residues within the single N-terminal kringle domain are identical to residues at positions 91-94 of SEQ ID NO;

    2; and

    (b) a C-terminal domain activation site and serine protease domain;

    wherein the polypeptide binds to immobilized lysine; and

    wherein the polypeptide is at least 95% identical to the sequence shown in SEQ ID NO;

    2.

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