Bone filling complex and method for fabricating the same
First Claim
Patent Images
1. A bone filling complex comprising:
- a matrix comprising a hydrogel-type hyaluronic acid derivative, wherein the hydrogel-type hyaluronic acid derivative is obtained by reacting a hyaluronic acid with a bis(sulfosuccinimmidyl)suberate or a dithiol-based crosslinker, wherein the dithiol-based derivative is a peptide which has cysteine at its opposite ends and an arginine-glycine-aspartic acid sequence interposed between the ends; and
a bone derivative, wherein the bone derivative is a calcium phosphate-based compound, filling the matrix.
1 Assignment
0 Petitions
Accused Products
Abstract
Provided is a bone filling complex and method of preparing the same. The bone filling complex includes a matrix including a hydrogel-type hyaluronic acid derivative; and a bone derivative filling the matrix For example, the bone filling complex can be used to regenerate an injured alveolar bone.
-
Citations
29 Claims
-
1. A bone filling complex comprising:
-
a matrix comprising a hydrogel-type hyaluronic acid derivative, wherein the hydrogel-type hyaluronic acid derivative is obtained by reacting a hyaluronic acid with a bis(sulfosuccinimmidyl)suberate or a dithiol-based crosslinker, wherein the dithiol-based derivative is a peptide which has cysteine at its opposite ends and an arginine-glycine-aspartic acid sequence interposed between the ends; and a bone derivative, wherein the bone derivative is a calcium phosphate-based compound, filling the matrix. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. A method of preparing a bone filling complex, the method comprising:
-
forming a matrix comprising a hydrogel-type hyaluronic acid derivative, wherein the forming of a matrix comprises reacting a hyaluronic acid with a bis(sulfosuccinimmidyl)suberate or a dithiol-based crosslinker, wherein the dithiol-based crosslinker is a peptide which has cysteine at its opposite ends and an arginine-glycine-aspartic acid sequence interposed between the ends; and filling the matrix with a bone derivative, wherein the bone derivative is a calcium phosphate-based compound. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
-
Specification