Antisense oligonucleotide modulation of STAT3 expression
First Claim
1. A compound comprising a modified oligonucleotide consisting of 15 to 30 linked nucleosides, wherein the modified oligonucleotide is complementary to an equal number of consecutive nucleobases selected from nucleobases 2941 to 3066 of SEQ ID NO:
- 154.
1 Assignment
0 Petitions
Accused Products
Abstract
Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression and for promotion of apoptosis are provided. Methods for treatment of diseases, particularly inflammatory diseases and cancers, associated with overexpression or constitutive activation of STAT3 or insufficient apoptosis are also provided.
23 Citations
15 Claims
- 1. A compound comprising a modified oligonucleotide consisting of 15 to 30 linked nucleosides, wherein the modified oligonucleotide is complementary to an equal number of consecutive nucleobases selected from nucleobases 2941 to 3066 of SEQ ID NO:
- 13. A composition comprising a modified oligonucleotide consisting of 15 to 30 linked nucleosides, wherein the modified oligonucleotide is complementary to an equal number of consecutive nucleobases selected from nucleobases 2941 to 3066 of SEQ ID NO:
Specification