Noninvasive glucose measurement

• US 8,185,182 B1
• Filed: 03/10/2009
• Issued: 05/22/2012
• Est. Priority Date: 10/14/2008
• Status: Active Grant

• Current Assignee: Ravi Shankar
• Original Assignee: Ravi Shankar
• Inventors: Shankar, Ravi
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): Reddy, Sunita
• Application Number:
  US12/381,242
• Time in Patent Office: 1,169 Days
• Field of Search: 600345-371, 600/547, 600309-323
• US Class Current: 600/347
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

An apparatus and method for measuring the blood glucose level of a diabetic using insulin is noninvasive. The apparatus includes two plethysmographs that sense the blood in two fingers simultaneously. The electrodes in the plethysmographs are immersed in conductive liquids. One liquid has electric conductivity equal to blood. The other liquid is more conductive than blood. Signals from the fingers are compared to signals obtained earlier when glucose levels were known from conventional measurements. An alternative embodiment employs a single plethysmograph with one set of electrodes in a surrounding chamber and a second set of electrodes against the skin surface.

Claims

1. Apparatus for noninvasive measuring of blood glucose level comprising:

a first digit encircling liquid chamber with a first electrode assembly affixed to an inner surface of an outer wall of the chamber, the first electrode assembly including a first pair of spaced-apart signal electrodes and a pair of electrodes positioned beside the first pair of spaced-apart signal electrodes through which an electric current is fed into the chamber;

a second digit encircling liquid chamber with a second electrode assembly affixed to an inner surface of an outer wall of the chamber, the second electrode assembly including a second pair of spaced-apart signal electrodes and a pair of electrodes positioned beside the second pair of spaced-apart signal electrodes through which an electric current is fed into the chamber;

liquid in the first chamber having electrical conductivity substantially equal to electrical conductivity of fluid in the digit;

liquid in the second chamber having electrical conductivity substantially more than the electrical conductivity of fluid in the digit; and

pulsatile signal processing circuitry connected to the first and second pairs of signal electrodes to compare electrical signals on the two pairs of signal electrodes to calibration signals received during known glucose levels to thereby distinguish between normal glucose concentration, high glucose concentration, and low glucose concentration.

2. The apparatus of claim 1 in which each chamber has an encircling rigid vertical wall, a closed bottom, and an open top through which the digit is to be inserted;

and the electrode assembly is affixed to an inside surface of the vertical wall.

3. The apparatus of claim 1 in which each chamber has an annular volume defined by an encircling rigid outer wall, a flexible inner wall, and two flexible end members sealingly joining the inner and outer walls;

the electrode assembly is affixed to an inside surface of the outer wall; and

an electrode assembly is additionally affixed to the outer surface of the flexible inner wall of at least one chamber to contact the surface of the digit.

4. The apparatus of claim 1 in which the signal processing circuitry comprises:

real time signal acquisition, processing, and storing;

a process for removing motion artifacts and noise due to instrumentation and ac power;

storage of signals acquired during calibration at known blood glucose levels;

comparison of trends in stored signals with calibration signals; and

signature analysis.

5. A method for measuring blood glucose level comprising:

encircling a first digit with a first digit encircling liquid chamber with a first electrode assembly including a first pair of spaced-apart signal electrodes and a pair of electrodes positioned beside the first pair of spaced-apart signal electrodes through which an electric current is fed into the chamber;

encircling a second digit with a second digit encircling liquid chamber with a second electrode assembly including a second pair of spaced-apart signal electrodes and a pair of electrodes positioned beside the second pair of spaced-apart signal electrodes through which an electric current is fed into the chamber;

providing a liquid in the first chamber having electrical conductivity substantially equal to the electrical conductivity of the fluid in the digit;

providing a liquid in the second chamber having electrical conductivity substantially more than the electrical conductivity of the fluid in the digit; and

using a pulsatile signal processing circuitry connected to the first and second pairs of signal electrodes to compare electrical signals on the two pairs of signal electrodes to calibration signals received during known glucose levels to thereby distinguish between normal glucose concentration, high glucose concentration, and low glucose concentration.

6. Apparatus for noninvasive measuring of blood glucose level comprising:

a digit encircling liquid chamber having an annular volume defined by an encircling rigid outer wall, a flexible inner wall, and two flexible end members sealingly joining the inner and outer walls;

a first electrode assembly affixed to an inner surface of the outer wall, the first electrode assembly including a first pair of spaced-apart signal electrodes and a pair of electrodes positioned beside the first pair of spaced-apart signal electrodes through which an electric current is fed into the chamber;

a second electrode assembly affixed to an outer surface of the inner wall to contact the digit, the second electrode assembly including a second pair of spaced-apart signal electrodes and a second pair of electrodes positioned beside the second pair of spaced-apart signal electrodes through which an electric current is fed;

liquid in the chamber having electrical conductivity;

pulsatile signal processing circuitry connected to the first and second pairs of signal electrodes to compare electrical signals on the two pairs of signal electrodes to calibration signals received during known glucose levels to thereby distinguish between normal glucose concentration, high glucose concentration, and low glucose concentration.