Multi-functional, discrete and mutually exclusive method for determining concentrations of gases in a gaseous mixture

• US 8,185,325 B2
• Filed: 02/10/2009
• Issued: 05/22/2012
• Est. Priority Date: 02/11/2008
• Status: Active Grant

• Current Assignee: Gennadiy Nosovitskiy, Pavel Nosovitskiy
• Original Assignee: Gennadiy Nosovitskiy, Pavel Nosovitskiy
• Inventors: Nosovitskiy, Pavel, Nosovitskiy, Gennadiy
• Primary Examiner(s): Brusca, John S
• Application Number:
  US12/322,989
• Publication Number:
  US 20100004554A1
• Time in Patent Office: 1,197 Days
• Field of Search: None
• US Class Current: 702/24
• CPC Class Codes: A61B 5/082 Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath A61B5/083, A61B5/091 take precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: G01N 27/122 Circuits particularly adapted therefor, e.g. linearising circuits
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath

Abstract

Method and device for detection and quantitative and qualitative analysis of components in a gaseous mixture distinguished by high selectivity and high resolution.

Method allows to distinguish the influence of individual gases, by themselves or in a mixture, on the microstructure of a sensor'"'"'s sensitive layer and utilizing the variations of measured parameters to analyze and derive the characteristics of gases, for example, the concentration of a gas or multiple gases in a mixture.

As an example, the method could be utilized in medicine for non-invasive detection of the blood glucose level in diabetics.

Device realizing the method is described.

Claims

1. A method for determining a concentration of a component of a sample, the method comprising:

[1] trapping a volume of the sample in a trapping chamber;

[2] passing at least a portion of the trapped volume of sample into a sensing chamber, wherein the sensing chamber includes or is in connection with a sensor;

[3] detecting a change in current as a result of interaction of the sample with a sensor;

[4] using at least Mathieu'"'"'s Equation with a value for each of its initial conditions, to determine when a value associated with the detected current is in a stable domain;

[5] when the value associated with the detected current is not in a stable domain, varying one or more of the initial conditions of Mathieu'"'"'s Equation, and repeating the determining until the detected current is in a stable domain; and

[6] determining the concentration of the component of the sample using the value associated with the detected current.

2. The method of claim 1, wherein the sample is a gas.

3. The method of claim 1, wherein the sample is a liquid.

4. The method of claim 1, wherein the value associated with the detected current is a value of the detected current.

5. The method of claim 1, wherein a temperature of the sensor is set to a different temperature from that as used during a previous determining of the concentration of the component of the sample.

6. The method of claim 1, wherein a pressure of the trapped volume of sample is varied from a pressure of the trapped volume of sample as measured during a previous determining of the concentration of the component of the sample.

7. The method of claim 1, wherein Mathieu'"'"'s Equation is of a form D^2x/dt^2+lambda^2(1+mu*f(t))x=0 where lambda represents a numeric constant, where mu represents another numeric constant, and where t represents time.

8. The method of claim 1, wherein the trapping of the volume of the sample in the trapping chamber includes trapping the volume of the sample for a sufficient time so that a substantial portion of the trapped volume of the sample is isolated from an influence of an atmospheric temperature and isolated from an influence of an atmospheric pressure.

9. The method of claim 1, wherein the trapping of the volume of the sample in the trapping chamber includes trapping the volume of the sample sufficiently so as to avoid a measurable amount of contamination.

10. The method of claim 1, wherein a stable domain is a numeric domain where values can be predicted in accordance with the said Mathieu'"'"'s Equation, and wherein an unstable domain is a numeric domain where a resulting value is unreliable.

11. The method of claim 1, wherein the determining the concentration of the component of the sample includes the use of parametric vibrations when the value associated with the detected current is approximately at a border between a stable domain and an unstable domain.

12. The method of claim 1, wherein the method further comprises using a unique identifier of, or a particular value associated with, the component of the sample to distinguish the component from one or more other components of the sample.

13. The method of claim 1, wherein the sample includes a second component, and wherein the method further comprises:

performing steps [2] through [5] for the second component; and

determining the concentration of the second component of the sample using the value associated with the detected current in respect to the second component.

14. The method of claim 1, before using at least Mathieu'"'"'s Equation, selecting values for the initial conditions for Mathieu'"'"'s Equation such that when determining the value associated with the detected current is more likely to in a stable domain.

15. A device for detecting a concentration of a component of sample, the device comprising:

a trapping chamber for containing a volume of the sample;

a sensing chamber, wherein the sensing chamber includes a sensor, and wherein the sensor is capable of generating a change in current as a result of interaction with the component of the sample;

a memory configured with instructions to;

use at least Mathieu'"'"'s Equation with a value for each of its initial conditions to determine when a value associated with the change in current is in a stable domain;

when the value associated with the change in current is not in a stable domain, vary one or more of the initial conditions of Mathieu'"'"'s Equation, and

trigger a repeating of determining when the value associated with the change in current is in a stable domain; and

an electrical output to transfer a value associated with the change in current to another component.

16. The device of claim 15, wherein the device further comprises:

a control unit that is capable of;

manipulating one or more of the initial conditions of Mathieu'"'"'s Equation;

operating the sensing chamber; and

interact with the memory and electrical output.

17. One or more non-transitory physical computer-readable media configured with instructions for performing a method, the method comprising:

trapping a volume of the sample in a trapping chamber;

passing the trapped volume of sample into a sensing chamber, wherein the sensing chamber includes or is in connection with a sensor;

instructing a processor to detect a value related to a change in current as a result of interaction of the sample with the sensor;

instructing the processor to perform a calculation using Mathieu'"'"'s Equation;

instructing the processor to determine when a value associated with the detected current is in a stable domain;

when the value associated with the detected current is not in a stable domain, varying one or more of the initial conditions of Mathieu'"'"'s Equation, and repeating the determining until the detected current is in a stable domain; and

determining the concentration of the component of the sample.