Systems and methods for particle focusing in microchannels
First Claim
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1. A system for focusing particles suspended within a moving fluid, the system comprising:
- a substrate;
at least one channel provided on the substrate, the at least one channel having an inlet, an outlet, a plurality of sides, wherein the relative geometry of the sides defines an aspect ratio, and a channel hydraulic diameter (Dh), wherein the at least one channel is configured to allow a fluid having a substantially constant kinematic viscosity (v) that includes suspended particles, each having a particle diameter (a), to flow therethrough; and
a pumping element designed to drive the fluid that includes the suspended particles through the at least one channel;
wherein when the fluid that includes the suspended particles is flowed through the at least one channel, and the pumping element drives the fluid that includes the suspended particles at a maximum channel velocity (Um) resulting in a laminar fluid flow and a particle Reynolds Number (Rp)) of greater than or equal to 0.2, wherein the particle Reynolds number is defined as
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Abstract
Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines.
196 Citations
20 Claims
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1. A system for focusing particles suspended within a moving fluid, the system comprising:
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a substrate; at least one channel provided on the substrate, the at least one channel having an inlet, an outlet, a plurality of sides, wherein the relative geometry of the sides defines an aspect ratio, and a channel hydraulic diameter (Dh), wherein the at least one channel is configured to allow a fluid having a substantially constant kinematic viscosity (v) that includes suspended particles, each having a particle diameter (a), to flow therethrough; and a pumping element designed to drive the fluid that includes the suspended particles through the at least one channel; wherein when the fluid that includes the suspended particles is flowed through the at least one channel, and the pumping element drives the fluid that includes the suspended particles at a maximum channel velocity (Um) resulting in a laminar fluid flow and a particle Reynolds Number (Rp)) of greater than or equal to 0.2, wherein the particle Reynolds number is defined as - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification