Therapeutic member including a rail used in brachytherapy and other radiation therapy

• US 8,187,159 B2
• Filed: 02/26/2009
• Issued: 05/29/2012
• Est. Priority Date: 07/22/2005
• Status: Expired due to Fees

• Current Assignee: Theragenics Corporation (Juniper Investment Co. LLC)
• Original Assignee: Uk Biocompatibles
• Inventors: Lamoureux, Gary A., Matons, James, Johnston, Warren, Bouffard, Matthew, Rice, Warren
• Primary Examiner(s): Marmor, II, Charles A
• Assistant Examiner(s): KUHLMAN, CATHERINE BURK
• Application Number:
  US12/393,349
• Publication Number:
  US 20090203953A1
• Time in Patent Office: 1,188 Days
• Field of Search: 600 1- 8, 252/644, 424 111- 189
• US Class Current: 600/8
• CPC Class Codes: A61N 2005/1023 Means for creating a row of seeds, e.g. spacers
• CPC Class Codes: A61N 2005/1024 Seeds
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle comprises a single radioactive source encapsulated by a bio-absorbable material having an outer surface including one or more ribs encircling the single radioactive source, a leading edge endcap rib and a trailing edge endcap rib. The one or more ribs reduces a tendency of the member to migrate and rotate within a patient'"'"'s body after implantation. The encapsulating material further includes a first rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, and a second rail formed from the bio-absorbable material extending at least from opposite sides of the outer surface of the encapsulating material along the longitudinal axis of the therapeutic member, the second rail arranged in a plane substantially perpendicular to a plane in which the first rail is arranged.

Claims

1. A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle, comprising:

a radioactive source;

an outer structure encapsulating at least a portion of said radioactive source;

said outer structure including a plurality of protrusions that reduce a tendency of the therapeutic member to migrate and rotate within a body of a patient after implantation;

said protrusions including first and second radial ribs encircling said radioactive source and spaced apart from one another along at least a portion of a longitudinal axis of said radioactive source; and

said outer structure also including one or more longitudinal rails;

wherein at least a portion of each said longitudinal rail extends between and thereby ties together said first and second radial ribs.

2. The therapeutic member of claim 1, wherein said outer structure comprises a polymeric material molded to encapsulate said at least a portion of said radioactive source.

3. The therapeutic member of claim 1, wherein said outer structure comprises a polymeric material molded to completely encapsulate said radioactive source.

4. The therapeutic member of claim 1, wherein said radioactive source comprises a radioactive seed that includes radioactive material contained within a metallic housing having a substantially smooth outer surface without any protrusions.

5. The therapeutic member of claim 1, wherein each of said one or more longitudinal rails is generally perpendicular to said radial ribs.

6. The therapeutic member of claim 1, wherein:

said protrusions also include a first end cap rib located at a first longitudinal end of said outer structure and a second end cap rib located at a second longitudinal end of said outer structure;

said first and second radial ribs encircling said radioactive source are located between said first end cap rib and said second end cap rib; and

said first end cap rib, said first and second radial ribs, and said second end cap rib are tied together by each said longitudinal rail.

7. The therapeutic member of claim 1, wherein at least a portion each said longitudinal rail extends further from said radioactive source than said radial ribs in order to substantially center the therapeutic member in a lumen of a needle.

8. The therapeutic member of claim 1, further including at least one material including a drug, hormone or other therapeutic material or an adhesive material coating at least a portion of at least one of said radial ribs or at least a portion of a space between said radial ribs.

9. The therapeutic member of claim 1, wherein at least a portion of a said longitudinal rail includes serrations, teeth and/or irregularities to assist in reducing a tendency of the therapeutic member to migrate and rotate within a body of a patient after implantation.

10. The therapeutic member of claim 1, wherein each of said one or more longitudinal rails is generally parallel to the longitudinal axis of said radioactive source and extends outward from opposite sides of said radioactive source.

11. The therapeutic member of claim 1, further comprising one or more further radioactive sources, each of which is at least partially encapsulated by said outer structure.

12. The therapeutic member of claim 11, wherein said outer structure includes a separate plurality of protrusions associated with each of said radioactive sources.

13. The therapeutic member of claim 12, wherein for each said radioactive source:

said separate plurality of protrusions associated with the said radioactive source include a first end cap rib, a second end cap rib and first and second radial ribs encircling said radioactive source between said first end cap rib and said second end cap rib; and

said outer structure includes one or more longitudinal rails that tie together said first end cap rib, said first and second radial ribs encircling said radioactive source, and said second end cap rib.

14. The therapeutic member of claim 12, further comprising a space defined by said outer structure between each adjacent pair of said radioactive sources, wherein at least a portion of said outer structure that defines each said space does not include any protrusions.

15. The therapeutic member of claim 12, wherein for each said radioactive source:

said separate plurality of protrusions associated with the said radioactive source include first and second radial ribs encircling the said radioactive source and spaced apart from another; and

said outer structure includes one or more longitudinal rails that tie together said first and second radial ribs.

16. A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle, comprising:

a radioactive source;

an outer structure molded to encapsulate the radioactive source and including

(a) a first end cap rib located at a first longitudinal end of said outer structure;

(b) a second end cap rib located at a second longitudinal end of said outer structure;

(c) one or more radial ribs encircling said radioactive source between said first end cap rib and said second end cap rib; and

(d) one or more longitudinal rails that tie together said first end cap rib, said one or more radial ribs encircling said radioactive source, and said second end cap rib.

17. The therapeutic member of claim 16, wherein said one or more radial ribs encircling said radioactive source comprise a first radial rib and a second radial rib encircling said radioactive source and spaced apart from one another between said first end cap rib and said second end cap rib.

18. The therapeutic member of claim 16, wherein each of said one or more longitudinal rails is generally perpendicular to each said radial rib encircling said radioactive source.

19. The therapeutic member of claim 16, wherein said radioactive source comprises a radioactive seed that includes radioactive material contained within a metallic housing having a substantially smooth outer surface without any protrusions.

20. A therapeutic member for use in brachytherapy deliverable to an implant site by way of a needle, comprising:

a radioactive source; and

a polymeric material molded to encapsulate said radioactive source;

wherein an outer surface of said polymeric material defines at least two radial ribs spaced apart from on another and encircling said radioactive source and one or more longitudinal rails that tie together said at least two radial ribs; and

wherein a thickness of the encapsulating polymeric material varies such that the thickness is greater where there is at least one of a said radial rib and a said longitudinal rail than where there is not at least one of a said radial rib and a said longitudinal rail.

21. The therapeutic member of claim 20, wherein said radioactive source comprises a radioactive seed that includes radioactive material contained within a metallic housing having a substantially smooth outer surface without any protrusions.