System for determining endothelial dependent vasoactivity

• US 8,187,196 B2
• Filed: 04/25/2008
• Issued: 05/29/2012
• Est. Priority Date: 12/09/2002
• Status: Expired due to Fees

• Current Assignee: Ramot at Tel Aviv University Limited (Tel Aviv University)
• Original Assignee: Ramot at Tel Aviv University Limited (Tel Aviv University)
• Inventors: Amitzur, Giora, Einav, Shmuel, Peleg, Eran, Zimerman, Elya
• Primary Examiner(s): Le, Miranda
• Assistant Examiner(s): TOTH, KAREN E
• Application Number:
  US12/149,100
• Publication Number:
  US 20080200820A1
• Time in Patent Office: 1,495 Days
• Field of Search: 600/485, 600/500
• US Class Current: 600/486
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02133 by using induced vibration of the blood vessel
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/0285 Measuring or recording phase velocity of blood waves
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

A method of determining endothelial dependent vasoactivity of a subject, the method is effected by recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel; extracting at least one parameter from the pressure-related signals; and using the at least one parameter to determine a change of at least one characteristic of the at least one blood vessel, the change being representative of endothelial functioning; thereby determining the endothelial dependent vasoactivity of the subject.

Claims

1. A system for determining endothelial dependent vasoactivity of a subject, the system comprising:

an arrangement of sensors for recording pressure-related signals of a plurality of locations adjacent to at least one blood vessel, said at least one blood vessel being in at least one organ of said subject;

a processing unit configured to extract at least one parameter from said pressure-related signals, and

a spectral analyzer configured for analyzing said at least one parameter and obtaining a frequency decomposition of said at least one parameter, said frequency decomposition being representative of the endothelial dependent vasoactivity of the subject;

wherein said at least one parameter comprises a parameter selected from the group consisting of elapsed time between two successive peaks of one or more of said pressure-related signals, and amplitude of one or more of said pressure-related signals.

2. The system of claim 1, further comprising electronic-calculation functionality for determining an autonomic nervous system activity of the subject.

3. The system of claim 2, wherein said processing unit is configured to calculate heart rate variability from said pressure-related signals thereby to determine said autonomic nervous system activity.

4. The system of claim 2, further comprising at least one electrocardiogram lead.

5. The system of claim 4, wherein said processing unit is operable to calculate heart rate variability from electrocardiogram signals sensed by said at least one electrocardiogram lead, thereby to determine said autonomic nervous system activity.

6. The system of claim 4, wherein said processing unit is configured to extract at least one additional parameter selected from the group consisting of a width of said pressure-related signals, and an elapsed time between peaks of electrocardiogram signals and peaks of said pressure-related signals.

7. The system of claim 1, further comprising a mechanism for stimulating said at least one blood vessel.

8. The system of claim 7, wherein said mechanism for stimulating said at least one blood vessel is selected from the group consisting of a mechanical mechanism, a thermal mechanism, a chemical mechanism an electrical mechanism, a mechanism for generating mental stress and a device for allowing the subject to perform physical exercise.

9. The system of claim 7, wherein said mechanism is configured to apply external pressure on said at least one blood vessel.

10. The system of claim 9, wherein said mechanism comprises a sphingomanometer.

11. The system of claim 7, wherein said mechanism is configured to reduce a temperature of said at least one blood vessel.

12. The system of claim 11, wherein said mechanism selected from the group consisting of a bath of fluid and a cuff of fluid, said fluid being at a predetermined temperature.

13. The system of claim 1, comprising a mechanism configured to reduce a temperature of an organ other than any of said at least one argan.

14. The system of claim 13, wherein said mechanism selected from the group consisting of a bath of fluid and a cuff of fluid, said fluid being at a predetermined temperature.

15. The system of claim 1, wherein said at least one blood vessel is selected from the group consisting of a brachial artery, a radial artery and a carotid artery.

16. The system of claim 1, wherein said at least one characteristic of said at least one blood vessel is selected from the group consisting of a radius of said at least one blood vessel and an elastic modulus of said at least one blood vessel.