Porous synthetic vascular grafts with oriented ingrowth channels
First Claim
Patent Images
1. A method of making a prosthesis comprising the steps of:
- preparing a paste comprising a graft material solution and an extractable filler;
depositing a layer of the paste onto a mandrel, wherein the mandrel has a diameter about equal to a desired inside diameter of the vascular graft prosthesis;
winding an extractable fiber onto the layer of paste;
successively depositing additional layers of the paste and winding the extractable fiber onto each layer of the paste until a desired thickness of the vascular graft prosthesis is achieved;
precipitating graft material from the graft material solution; and
extracting the fiber from the graft material.
0 Assignments
0 Petitions
Accused Products
Abstract
A vascular prosthesis is constructed from a structure having interconnected, helically oriented channel-porosity to allow oriented ingrowth of connective tissue into a wall of the prosthesis. The prosthesis can have a small internal diameter of 6 mm or less. Several different methods can be used to produce the prosthesis, including a fiber winding and extraction technique, a melt extrusion technique, and a particle and fiber extraction technique using either a layered method or a continuous method. Furthermore, mechanical properties of prosthesis are matched with mechanical properties of the host vessel, thereby overcoming problems of compliance mismatch.
54 Citations
28 Claims
-
1. A method of making a prosthesis comprising the steps of:
-
preparing a paste comprising a graft material solution and an extractable filler; depositing a layer of the paste onto a mandrel, wherein the mandrel has a diameter about equal to a desired inside diameter of the vascular graft prosthesis; winding an extractable fiber onto the layer of paste; successively depositing additional layers of the paste and winding the extractable fiber onto each layer of the paste until a desired thickness of the vascular graft prosthesis is achieved; precipitating graft material from the graft material solution; and extracting the fiber from the graft material. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
-
-
15. A method of making a prosthesis comprising the steps of:
-
preparing a paste comprising a graft material solution and an extractable filler; depositing a layer of the paste onto a mandrel, and simultaneously winding an extractable fiber onto the mandrel, until a desired thickness of the vascular graft prosthesis is achieved, wherein the mandrel has a diameter about equal to a desired inside diameter of the vascular graft prosthesis; precipitating graft material from the graft material solution; and extracting the fiber from the graft material. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
-
Specification