Expandable medical device for delivery of beneficial agent
First Claim
1. A method of forming an expandable medical device comprising:
- (a) forming a substantially cylindrical expandable medical device body formed of a plurality of struts with a plurality of through openings in the plurality of struts;
(b) forming a first solution of a first beneficial agent, first polymer carrier, and a first solvent;
(c) delivering the first solution into the openings;
(d) evaporating the first solvent to form a solid layer of first beneficial agent and first carrier;
(e) repeating steps (c) and (d); and
(f) forming a second solution of a second beneficial agent, a second polymer carrier, and a second solvent and delivering the second solution into the openings on top of the layers of first beneficial agent, wherein the second beneficial agent is different from the first beneficial agent.
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Accused Products
Abstract
An expandable medical device has a plurality of elongated struts joined together to form a substantially cylindrical device which is expandable from a cylinder having a first diameter to a cylinder having a second diameter. At least one of the plurality of struts includes at least one opening extending at least partially through a thickness of said strut. A beneficial agent is loaded into the opening within the strut in layers to achieve desired temporal release kinetics of the agent. Alternatively, the beneficial agent is loaded in a shape which is configured to achieve the desired agent delivery profile. A wide variety of delivery profiles can be achieved including zero order, pulsatile, increasing, decrease, sinusoidal, and other delivery profiles.
521 Citations
19 Claims
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1. A method of forming an expandable medical device comprising:
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(a) forming a substantially cylindrical expandable medical device body formed of a plurality of struts with a plurality of through openings in the plurality of struts; (b) forming a first solution of a first beneficial agent, first polymer carrier, and a first solvent; (c) delivering the first solution into the openings; (d) evaporating the first solvent to form a solid layer of first beneficial agent and first carrier; (e) repeating steps (c) and (d); and (f) forming a second solution of a second beneficial agent, a second polymer carrier, and a second solvent and delivering the second solution into the openings on top of the layers of first beneficial agent, wherein the second beneficial agent is different from the first beneficial agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification