Attachment of absorbable tissue scaffolds to fixation devices

• US 8,187,326 B2
• Filed: 05/22/2002
• Issued: 05/29/2012
• Est. Priority Date: 05/22/2002
• Status: Active Grant

• Current Assignee: Endo-Surgery, Inc.
• Original Assignee: Advanced Technologies and Regenerative Medicine, LLC
• Inventors: Hammer, Joseph J., Contiliano, Joseph H., Vyakarnam, Murty N., Brown, Kelly R.
• Primary Examiner(s): Stewart, Alvin J
• Application Number:
  US10/154,136
• Publication Number:
  US 20030220700A1
• Time in Patent Office: 3,660 Days
• Field of Search: 623 2372- 2376, 623/13.14, 623/13.15, 623/20.17, 623/23.56, 623/23.58, 623/16.11, 623 236- 2363, 623/18.11, 623/14.12, 623/17.11, 623/17.16, 623/11.11, 606/60, 606246-249, 606/151, 606/154, 156/308.2
• US Class Current: 623/16.11
• CPC Class Codes: A61B 17/0642 for bones, e.g. for osteosynthesis or connecting tendon to bone
• CPC Class Codes: A61B 2017/00004 (bio)absorbable, (bio)resorbable, resorptive for implantable prostheses A61F2210/0004
• CPC Class Codes: A61B 2017/0646 for insertion into cartillege, e.g. meniscus
• CPC Class Codes: A61B 2017/0647 having one single leg, e.g. tacks
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30749 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30065 thermoplastic, i.e. softening or fusing when heated, and hardening and becoming rigid again when cooled
• CPC Class Codes: A61F 2002/30233 Stepped cylinders, i.e. having discrete diameter changes
• CPC Class Codes: A61F 2002/30324 differing in thickness
• CPC Class Codes: A61F 2002/30448 using adhesives
• CPC Class Codes: A61F 2002/30677 Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
• CPC Class Codes: A61F 2002/30751 for attaching cartilage scaffolds to underlying bone
• CPC Class Codes: A61F 2002/30766 Scaffolds for cartilage ingrowth and regeneration
• CPC Class Codes: A61F 2002/30878 with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
• CPC Class Codes: A61F 2002/30879 Ribs
• CPC Class Codes: A61F 2002/30891 Plurality of protrusions
• CPC Class Codes: A61F 2002/30957 : using a positive or a negative model, e.g. moulds
• CPC Class Codes: A61F 2002/30971 : Laminates, i.e. layered products
• CPC Class Codes: A61F 2210/0004 : bioabsorbable
• CPC Class Codes: A61F 2210/0071 : thermoplastic
• CPC Class Codes: A61F 2220/005 : using adhesives
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2250/0036 : differing in thickness
• CPC Class Codes: A61F 2310/00017 : Iron- or Fe-based alloys, e.g. stainless steel
• CPC Class Codes: A61F 2310/00023 : Titanium or titanium-based alloys, e.g. Ti-Ni alloys
• CPC Class Codes: A61F 2310/00029 : Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
• CPC Class Codes: A61F 2310/00179 : Ceramics or ceramic-like structures
• CPC Class Codes: A61F 2310/00203 : containing alumina or aluminium oxide
• CPC Class Codes: A61F 2310/00239 : containing zirconia or zirconium oxide ZrO2
• CPC Class Codes: A61F 2310/00293 : containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00329 : Glasses, e.g. bioglass
• CPC Class Codes: A61F 2310/00341 : Coral, e.g. aragonite, porite
• CPC Class Codes: A61F 2310/00353 : Bone cement, e.g. polymethylmethacrylate or PMMA
• CPC Class Codes: A61F 2310/00359 : Bone or bony tissue
• CPC Class Codes: A61F 2310/00365 : Proteins; Polypeptides; Degradation products thereof
• CPC Class Codes: A61L 27/18 : obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/58 : Materials at least partially resorbable by the body
• CPC Class Codes: C08L 67/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

The present invention relates to tissue scaffold implant devices useful in the repair and/or regeneration of diseased and/or damaged musculoskeletal tissue and that include a tissue scaffold component fixedly attached to a scaffold fixation component via a polymeric adhesive layer, and to methods of making such tissue scaffold implant devices.

Claims

1. A tissue scaffold implant device, comprising:

a non-woven textile tissue scaffold component having a top surface and a bottom surface, the tissue scaffold component comprising a soluble polymer,

a tissue scaffold support, having a top surface and a fixation post integral therewith and extending opposite from said top surface, the tissue scaffold support comprising a soluble thermoplastic polymer, and

an adhesive layer between said scaffold component and said top surface of said tissue scaffold support, said adhesive layer comprising a soluble polymer having a top surface and a bottom surface, the bottom surface of the scaffold component is fixedly attached to the top surface of the adhesive layer and the bottom surface of the adhesive layer is fixedly attached to the top surface of the scaffold support,

and

said soluble polymer of the tissue scaffold component is selected from the group consisting of polyalkylene oxalates, polyamides, polycarbonates, polyorthoesters, polyoxaesters, polyamidoesters, polyanhydrides and polyphosphazenes, and aliphatic polyesters selected from the group consisting of glycolide, ε

-caprolactone, p-dioxanone (1,4-dioxan-2-one), trimethylene carbonate (1,3-dioxan-2-one), δ

-valerolactone, β

-butyrolactone, ε

-decalactone, 2,5-diketomorpholine, pivalolactone, α

,α

-diethylpropiolactone, ethylene carbonate, ethylene oxalate, 3-methyl-1,4-dioxane-2,5-dione, 3,3-diethyl-1,4-dioxan-2,5-dione, γ

-butyrolactone, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, 6,6-dimethyl-dioxepan-2-one and 6,8-dioxabicycloctane-7-one.

2. The device of claim 1 wherein said adhesive layer soluble polymer is thermoplastic.

3. The device of claim 1, wherein the top surface of said tissue scaffold support is non-porous.

4. The device of claim 1, wherein the scaffold support comprises a biocompatible ceramic.

5. The device of claim 1, wherein the tissue scaffold component and the scaffold support comprise different bioabsorbable polymers.

6. The device of claim 5, wherein the tissue scaffold component is a wet-laid nonwoven textile comprising 90 mole % PGA/10 mole % PLA copolymer fibers and the scaffold support comprises 85 mole % PLA/15 mole % PGA copolymer.