Compound material analyte sensor

• US 8,187,433 B2
• Filed: 10/03/2006
• Issued: 05/29/2012
• Est. Priority Date: 06/16/2003
• Status: Active Grant

• Current Assignee: Konamite Limited
• Original Assignee: Isense Corporation
• Inventors: Ward, W. Kenneth, Sass, Richard G.
• Primary Examiner(s): Ball, J. Christopher
• Application Number:
  US11/538,340
• Publication Number:
  US 20070129619A1
• Time in Patent Office: 2,065 Days
• Field of Search: 600/345, 600/347, 600/365, 600/585, 204/403.01, 204/290.14, 205/792, 205/794.5
• US Class Current: 204/290.14
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: Y10T 29/49 Method of mechanical manufacture

Abstract

A sensing element adapted to, at least in part, be inserted into a mammalian body. The sensing element is made up of a core of a structurally robust metal and a plated portion made of an electrochemically active metal conjoined to at least a portion of the core. This sensing element may be used as part of a method for the continuous or intermittent monitoring of an analyte within a mammalian body. The method includes inserting at least a portion of the sensing element into the mammalian body and measuring any electric current produced by at least of portion of the sensor.

Claims

1. An analyte sensing element, comprising:

a structurally flexible core having an outer surface; and

a continuous layer of electrochemically active metal surrounding, covering, and in contact with said outer surface of said core, wherein the electrochemically active metal prevents body fluid from contacting said core and has at least one sensing surface, wherein said layer of electrochemically active metal is at least partially surrounded by a membrane system comprising an enzyme.

2. The analyte sensing element of claim 1, wherein said electrochemically active metal comprises a noble metal.

3. The analyte sensing element of claim 2, wherein said noble metal comprises at least one of platinum, palladium, and gold.

4. The analyte sensing element of claim 1, wherein said core comprises nitinol.

5. The analyte sensing element of claim 1, wherein said core comprises tantalum.

6. The analyte sensing element of claim 1, wherein said core is round in cross-section.

7. The analyte sensing element of claim 1, wherein said outer surface of said core comprises a passivated oxide surface.

8. The analyte sensing element of claim 1, wherein said layer of electrochemically active metal is at least partially surrounded by polyimide.

9. The analyte sensing element of claim 1, wherein said analyte sensing element is adapted to sense glucose.

10. The analyte sensing element of claim 1, wherein said analyte sensing element is adapted for at least partial implantation into a body.

11. The analyte sensing element of claim 1, wherein said core further comprises at least a first end, and wherein said electrochemically active layer further surrounds, covers, and contacts said at least a first end of said core.

12. An analyte sensing element, comprising:

a core of polymeric material or glass fiber having an outer surface; and

a continuous layer of electrochemically active metal surrounding, covering, and in contact with said outer surface of said core, wherein the electrochemically active metal prevents body fluid from contacting said core and has at least one sensing surface, wherein said layer of electrochemically active metal is at least partially surrounded by a membrane system comprising an enzyme.

13. The analyte sensing element of claim 12, wherein said layer of electrochemically active metal comprises at least one of platinum, palladium, and gold.

14. An analyte sensing element, comprising:

a core of stainless steel having an outer surface; and

a continuous layer of electrochemically active metal surrounding, covering, and in contact with said outer surface of said core, wherein the electrochemically active metal prevents body fluid from contacting said core and has at least one sensing surface, wherein said layer of electrochemically active metal is at least partially surrounded by a membrane system.

15. The analyte sensing element of claim 14, wherein said layer of electrochemically active metal comprises at least one of platinum, palladium, and gold.

16. An analyte sensing element, comprising:

a wire core of stainless steel having an outer surface;

a continuous layer of gold surrounding, covering, and in contact with said outer surface of said core, wherein the layer of gold prevents body fluid from contacting said core; and

a layer of platinum surrounding, covering, and in contact with said layer of gold, wherein said layer of platinum is at least partially surrounded by a membrane system.