Methods and apparatus for isolating platelets from blood
First Claim
1. A method for separating platelets from blood for application to a patient in a medical treatment, comprising:
- placing the blood in a container above a moveable surface that at least partially defines a volume by a sidewall extending from a top to a bottom;
sedimenting platelets from the blood placed in the container near the moveable surface within the container;
accessing the volume through at least one of two access ports passing into the container through a cap at the top of the container; and
withdrawing at least a portion of the sedimented platelets while venting the container through a vent formed in the cap.
1 Assignment
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Accused Products
Abstract
A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
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Citations
21 Claims
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1. A method for separating platelets from blood for application to a patient in a medical treatment, comprising:
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placing the blood in a container above a moveable surface that at least partially defines a volume by a sidewall extending from a top to a bottom; sedimenting platelets from the blood placed in the container near the moveable surface within the container; accessing the volume through at least one of two access ports passing into the container through a cap at the top of the container; and withdrawing at least a portion of the sedimented platelets while venting the container through a vent formed in the cap. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for separating platelets from blood for application to a patient in a medical treatment, comprising:
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placing the blood in a container at least partially defining a volume by a sidewall extending from a top to a bottom; positioning a float in the container near the bottom, wherein the float is operable to move towards the top of the container; centrifuging the container, the float, and the blood placed in the container to; cause the float to move upward within the container during the centrifuging from the near the bottom of the container such that a layer of erythrocytes forms on a collection surface of the float, and sediment platelets from the blood placed in the container on the layer of erythrocytes; and accessing the volume through at least one of two separate access ports passing into the container at the top of the container while venting the container through a vent separate passing through the top of the container, wherein the two access ports and at least an opening for the vent are all defined separately by a cap that engages the sidewall at the top of the container. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
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18. A method for separating platelets from blood for application to a patient in a medical treatment, comprising:
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placing the blood in a container at least partially defining a volume by a sidewall extending from a top to a bottom; positioning a float component in the container near the bottom, wherein the float component is operable to move towards the top of the container and the float has sidewalls that are substantially parallel to the sidewalls of the container when the float is near the bottom of the container; centrifuging the container, the float component, and the blood placed in the container to; cause the float component to move within the container during the centrifuging from near the bottom of the container such that a layer of erythrocytes form on a collection surface of the float component, and sediment platelets from the blood placed in the container on the layer of erythrocytes and near a low region defined near a center of the float component; ceasing centrifugation to allow the float component to be held at a selected position within the container via cooperation of the sidewall and the sidewall of the float component; accessing the volume through at least one of two access ports passing into the container through a cap integrated at the top of the container, wherein the two ports are separately defined through the cap; and withdrawing directly at least a portion of the sedimented platelets in the container from near the low region while venting the container through a vent defined through the cap separate from the two ports in the cap of the container and the sidewalls of the float remain substantially parallel to sidewalls of the container. - View Dependent Claims (19, 20, 21)
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Specification