Electrochemical gas sensor with a hydrophilic membrane coating

• US 8,187,543 B2
• Filed: 04/14/2005
• Issued: 05/29/2012
• Est. Priority Date: 04/26/2004
• Status: Active Grant

• Current Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Original Assignee: Roche Diagnostics Operations Incorporated (Roche Holding AG)
• Inventors: Werkl, Dietmar, Leiner, Marco, Weis, Léonie
• Primary Examiner(s): Ball, J. Christopher
• Application Number:
  US11/106,125
• Publication Number:
  US 20050249885A1
• Time in Patent Office: 2,602 Days
• Field of Search: 427/443.2, 204/431, 204/410, 204/411, 204421-429, 205/781, 2057835-785, 205/787, 73/232.1, 73/233.2, 422 83- 98, 436/68, 436/137
• US Class Current: 422/98
• CPC Class Codes: G01N 27/404 Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid , e.g. Clark-type oxygen sensors

Abstract

An electrochemical gas sensor is provided comprising a gas-permeable and substantially ion- and liquid-impermeable membrane for separating an aqueous outer solution and an inner electrolyte solution comprising a gas-permeable film of a hydrophilic polymer consisting essentially of non-covalently cross-linked polymer chains, wherein the film is present directly at least on the side of the membrane facing the aqueous outer solution, which has a surface wettability for the aqueous outer solution that is higher than the surface wettability of the membrane for the aqueous outer solution.

Claims

1. An electrochemical gas sensor comprising:

a gas-permeable and substantially ion-impermeable and liquid-impermeable membrane for separating an aqueous outer solution and an inner electrolyte solution, and a gas-permeable film of a hydrogel-forming hydrophilic polymer consisting essentially of non-covalently cross-linked polymer chains, wherein the film is present directly at least on the side of the membrane facing the aqueous outer solution, said film having a surface wettability for the aqueous outer solution that is higher than the surface wettability of the membrane for the aqueous outer solution, said sensor further comprising a channel for transport of said aqueous outer solution, said channel comprising at least one surface in contact with said aqueous outer solution.

2. The electrochemical gas sensor of claim 1, wherein the hydrophilic polymer is soluble in organic solvents and solvent mixtures.

3. The electrochemical gas sensor of claim 1, wherein the hydrophilic polymer is substantially insoluble in aqueous solutions.

4. The electrochemical gas sensor of claim 1, wherein the hydrophilic polymer is substantially insoluble in aqueous outer solutions.

5. The electrochemical gas sensor of claim 1, wherein the hydrophilic polymer is substantially insoluble in sample liquids.

6. The electrochemical gas sensor of claim 1, wherein the hydrophilic polymer is a polyether-polyurethane copolymer.

7. The electrochemical gas sensor of claim 1, wherein the thickness of the film of hydrophilic polymer is between about 0.01 and about 1.2 μ

m.

8. The electrochemical gas sensor of claim 1, wherein the thickness of the film of hydrophilic polymer is between about 0.01 and about 0.2 μ

m.

9. The electrochemical gas sensor of claim 1, wherein the membrane comprises a gas-permeable plastic.

10. The electrochemical gas sensor of claim 9, wherein the gas-permeable plastic is selected from polytetrafluoroethylene, polypropylene, and polyethylene.

11. The electrochemical gas sensor of claim 1, wherein the at least one channel surface in contact with said aqueous outer solution is coated with a film of the hydrophilic polymer.

12. A gas-permeable and substantially ion-impermeable and liquid-impermeable membrane for use in the electrochemical gas sensor of claim 1, wherein a gas-permeable film of a hydrophilic polymer is present directly at least on the side of the membrane facing the aqueous outer solution, said film having a surface wettability for the aqueous outer solution that is higher than the surface wettability of the membrane for the aqueous outer solution and that the hydrophilic polymer consists essentially of non-covalently cross-linked polymer chains.

13. A process for coating membranes as claimed in claim 12 with a gas-permeable film of a hydrophilic polymer, comprising:

a) dissolving the hydrophilic polymer in an organic solvent or solvent mixture to create a polymer solution;

b) applying the polymer solution to at least one side of the membrane; and

c) removing the organic solvent or solvent mixture such that the hydrophilic polymer is present in the form of a thin film at least on one side of the membrane.

14. The process of claim 13 further comprising subjecting the surface of the membrane to a physicochemical pre-treatment prior to step b).

15. The process of claim 14, wherein the physicochemical pre-treatment is a plasma treatment.

16. An electrochemical gas sensor comprising:

a gas-permeable and substantially ion-impermeable and liquid-impermeable membrane for separating an aqueous outer solution and an inner electrolyte solution, and a gas-permeable film of a hydrogel-forming hydrophilic polymer consisting essentially of non-covalently cross-linked polymer chains, wherein the film is present directly at least on the side of the membrane facing the aqueous outer solution, said film having a surface wettability for the aqueous outer solution that is higher than the surface wettability of the membrane for the aqueous outer solution, said sensor further comprising a channel for transport of said aqueous outer solution, said channel comprising at least one surface in contact with said aqueous outer solution, and wherein the thickness of the film of hydrophilic polymer is between about 0.01 and about 1.2 μ

m.