FcγRIIB specific antibodies and methods of use thereof
First Claim
1. A method for treating or ameliorating a B-cell malignancy or one or more symptoms thereof in a subject, said method comprising administering to a subject in need thereof a therapeutically effective amount of a Fcγ
- RIIB-specific antibody or antigen binding fragment thereof;
wherein said Fcγ
RIIB-specific antibody comprises a variable domain, wherein said Fcγ
RIIB-specific antibody or fragment thereof is produced from clone 2B6, having ATCC Accession No. PTA-4591, or from clone 3H7, having ATCC Accession No. PTA-4592, and wherein said antibody and said fragment thereof bind Fcγ
RIIB via said variable domain and bind to said Fcγ
RIIB with greater affinity than said antibody or fragment thereof bind Fcγ
RIIA.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The present invention also encompasses the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, as a single agent therapy for the treatment, prevention, management, or amelioration of a cancer, preferably a B-cell malignancy, particularly, B-cell chronic lymphocytic leukemia or non-Hodgkin'"'"'s lymphoma, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The present invention also encompasses the use of an anti-FcγRIIB antibody or an antigen-binding fragment thereof, in combination with other cancer therapies. The present invention provides pharmaceutical compositions comprising an anti-FcγRIIB antibody or an antigen-binding fragment thereof, in amounts effective to prevent, treat, manage, or ameliorate a cancer, such as a B-cell malignancy, an autoimmune disorder, an inflammatory disorder, an IgE-mediated allergic disorder, or one or more symptoms thereof. The invention further provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention with a vaccine composition.
-
Citations
15 Claims
-
1. A method for treating or ameliorating a B-cell malignancy or one or more symptoms thereof in a subject, said method comprising administering to a subject in need thereof a therapeutically effective amount of a Fcγ
- RIIB-specific antibody or antigen binding fragment thereof;
wherein said Fcγ
RIIB-specific antibody comprises a variable domain, wherein said Fcγ
RIIB-specific antibody or fragment thereof is produced from clone 2B6, having ATCC Accession No. PTA-4591, or from clone 3H7, having ATCC Accession No. PTA-4592, and wherein said antibody and said fragment thereof bind Fcγ
RIIB via said variable domain and bind to said Fcγ
RIIB with greater affinity than said antibody or fragment thereof bind Fcγ
RIIA. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- RIIB-specific antibody or antigen binding fragment thereof;
Specification