Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
First Claim
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1. An implantable medical device comprising:
- (a) a surface;
(b) a coating disposed on the surface comprising;
(i) a first material comprising a first transition metal oxide material in the form of a layer having a plurality of pores therein disposed on at least a portion of the surface, wherein a first therapeutic agent is disposed in at least some of the pores of the first transition metal oxide material;
(ii) a first polymer in the form of a layer disposed on at least a portion of the first transition metal oxide material, wherein the first polymer has a plurality of pores therein; and
(c) an outer region adjacent to the surface, wherein the outer region comprises a second material comprising a second transition metal oxide material different from the first transition metal oxide material, the second transition metal oxide material having a plurality of pores therein, and a second therapeutic agent disposed in at least some of the pores of the second transition metal oxide material;
wherein the first and second therapeutic agents are the same or different.
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Abstract
The invention relates generally to a medical device, such as an intravascular stent, for delivering a therapeutic agent to the body tissue of a patient, and a method for making such a medical device. More particularly, the invention pertains to a medical device having a metal oxide or metal material with a plurality of pores therein disposed on the surface of the medical device and a polymer disposed on the metal oxide or metal material. The invention also relates to medical devices having a surface and an outer region comprising a metal oxide or metal material having a plurality of pores therein and a polymer disposed on the metal oxide or metal material.
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Citations
16 Claims
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1. An implantable medical device comprising:
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(a) a surface; (b) a coating disposed on the surface comprising; (i) a first material comprising a first transition metal oxide material in the form of a layer having a plurality of pores therein disposed on at least a portion of the surface, wherein a first therapeutic agent is disposed in at least some of the pores of the first transition metal oxide material; (ii) a first polymer in the form of a layer disposed on at least a portion of the first transition metal oxide material, wherein the first polymer has a plurality of pores therein; and (c) an outer region adjacent to the surface, wherein the outer region comprises a second material comprising a second transition metal oxide material different from the first transition metal oxide material, the second transition metal oxide material having a plurality of pores therein, and a second therapeutic agent disposed in at least some of the pores of the second transition metal oxide material; wherein the first and second therapeutic agents are the same or different. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 14, 15, 16)
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13. An implantable medical device comprising:
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(a) an inner region having at least two surfaces, wherein the inner region is substantially non-porous; (b) an outer region adjacent to each surface of the inner region, wherein the outer region comprises a second material comprising a second transition metal oxide material in the form of a layer having a plurality of pores therein, and a second therapeutic agent disposed in at least some of the pores in the second transition metal oxide material; (c) a coating disposed on each of the outer regions comprising; (i) a first material comprising a first transition metal oxide material different from the second transition metal oxide material, the first transition metal oxide material in the form of a layer having a plurality of pores therein disposed on at least a portion of the surface, wherein a first therapeutic agent is disposed in at least some of the pores of the first transition metal oxide material; and (ii) a first polymer in the form of a layer disposed on at least a portion of the first transition metal oxide material, wherein the first polymer has a plurality of pores therein.
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Specification