Optical scanning system
First Claim
1. A chip for detecting a biologically active analyte, comprising a substrate wherein the substrate comprises a plurality of substantially parallel excitation waveguides, and a plurality of substantially parallel collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing;
- a coupling region at an edge of the substrate in optical communication with each excitation waveguide and configured to couple the excitation waveguides to light traveling parallel to and in the plane of the excitation waveguides from the edge of the substrate; and
a plurality of optical sensing sites each in optical communication with an intersection region.
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Abstract
An optical scanning system including a switchable light source, a detector, a substrate and a plurality of optical sensing sites, as well s methods and kits for use thereof are provided. The substrate is coupled to and in optical communication with the switchable light source and the detector. Additionally, the substrate includes a plurality of substantially parallel excitation waveguides, and a plurality of substantially parallel collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing. The plurality of optical sensing sites are each in optical communication with an intersection region.
150 Citations
50 Claims
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1. A chip for detecting a biologically active analyte, comprising a substrate wherein the substrate comprises a plurality of substantially parallel excitation waveguides, and a plurality of substantially parallel collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing;
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a coupling region at an edge of the substrate in optical communication with each excitation waveguide and configured to couple the excitation waveguides to light traveling parallel to and in the plane of the excitation waveguides from the edge of the substrate; and a plurality of optical sensing sites each in optical communication with an intersection region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 46, 49)
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33. A scanning sensing method comprising:
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delivering a sample suspected of containing a biologically active analyte to be detected to an optical sensing site of a chip comprising a substrate wherein the substrate comprises a plurality of substantially parallel excitation waveguides, and a plurality of substantially parallel collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing; and
a plurality of optical sensing sites each in optical communication with an intersection region;providing a first light wave using a switchable light source to one or more of the plurality of substantially parallel excitation waveguides in optical communication with the optical sensing site, wherein the first light wave is transducable by a sensor associated with the optical sensing site to a second light wave carried in one or more of the plurality of substantially parallel collection waveguides in optical communication with the optical sensing site and crossing the excitation waveguides; and detecting the second light wave using a detector in optical communication with the collection waveguides, wherein a measurable change in the first light waves occurs when the sensor interacts with the biologically active analyte. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A kit for assaying a sample for a biologically active analyte comprising:
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a chip comprising a substrate wherein the substrate comprises a plurality of substantially parallel excitation waveguides, and a plurality of substantially parallel collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing; a coupling region at an edge of the substrate in optical communication with each excitation waveguide and configured to couple the excitation waveguides to light traveling parallel to and in the plane of the excitation waveguides from the edge of the substrate; a plurality of optical sensing sites each in optical communication with an intersection region; packaging; and instructions for use of the chip in an optical scanning system. - View Dependent Claims (45)
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47. A chip for detecting a biologically active analyte, comprising a substrate wherein the substrate comprises a plurality of excitation waveguides and a plurality of collection waveguides, the excitation waveguides and collection waveguides arranged in a lateral plane so that the excitation waveguides and collection waveguides cross to form a two-dimensional array of intersection regions where the crossing of each excitation waveguide and collection waveguide provides evanescent optical communication with the intersection region at each crossing, further wherein the excitation waveguides are single-mode in a vertical dimension and multimode in a lateral dimension;
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a coupling region at an edge of the substrate in optical communication with each excitation waveguide and configured to couple the excitation waveguides to light traveling parallel to and in the plane of the excitation waveguides from the edge of the substrate; and a plurality of optical sensing sites each in optical communication with an intersection region. - View Dependent Claims (48)
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50. A scanning sensing method comprising:
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delivering a sample suspected of containing a biologically active analyte to be detected to an optical sensing site of a chip comprising a substrate wherein the substrate comprises a plurality of excitation waveguides, and a plurality of collection waveguides, the excitation waveguides and collection waveguides crossing to form a two-dimensional array of intersection regions where an excitation waveguide and a collection waveguide cross and provide optical communication with the intersection region at each crossing; and
a plurality of optical sensing sites each in optical communication with an intersection region;providing a first light from a light source in the plane of the substrate to one or more of the plurality of excitation waveguides in optical communication with the optical sensing site, wherein the first light is transducable by a sensor associated with the optical sensing site to emit light in one or more of the plurality of collection waveguides in optical communication with the optical sensing site and crossing the excitation waveguides; and detecting the emitted light using a detector in optical communication with the collection waveguides, wherein a measurable change in the first light occurs when the sensor interacts with the biologically active analyte.
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Specification