Use of toll-like receptor-9 agonists, toll-like receptor-4 antagonists, and/or nuclear oligomerization domain-2 agonists for the treatment or prevention of toll-like receptor-4-associated disorders

• US 8,188,058 B2
• Filed: 04/17/2008
• Issued: 05/29/2012
• Est. Priority Date: 04/19/2007
• Status: Active Grant

• Current Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Original Assignee: University of Pittsburgh of The Commonwealth System of Higher Education
• Inventors: Hackam, David J., Gribar, Steven C.
• Primary Examiner(s): McGarry, Sean
• Application Number:
  US12/104,816
• Publication Number:
  US 20080311112A1
• Time in Patent Office: 1,503 Days
• Field of Search: 435/6, 435/91.1, 435/455, 424/9.1, 514/1, 514/2, 514/44, 536/23.1
• US Class Current: 514/44.R
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/675 having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 1/06 Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: C07H 21/04 with deoxyribosyl as saccharide radical

Abstract

The present invention relates to the use of a TLR9 agonist and/or a TLR4 antagonist and/or a NOD2 agonist for treatment or prevention of disorders involving TLR4 activation, such as systemic sepsis and necrotizing enterocolitis.

Claims

1. A method of treating necrotizing enterocolitis in a subject in need of such treatment comprising administering, to the subject, an effective amount of a TLR9 agonist.

2. The method of claim 1, wherein the TLR9 agonist is an oligonucleotide comprising an unmethylated CpG dinucleotide.

3. The method of claim 1, which further comprises administration of an antibiotic.