Vitamin D analogs for obesity prevention and treatment
First Claim
1. A method for inhibiting adipocyte differentiation, inhibiting SCD-1 gene transcription, and/or reducing body fat in an animal subject in need thereof, comprising administering to the animal subject, an effective amount of a 19-nor vitamin D compound or a pharmaceutical composition comprising the compound, wherein the compound administered to the subject inhibits adipocyte differentiation, inhibits SCD-1 gene transcription, and/or reduces body fat in the animal subject, and further wherein the compound is selected from a compound of formula IID, a compound of formula IIE, a compound of formula IIF, a compound of formula IIG, a compound of formula IIH, a compound of formula IIJ, a compound of formula IIK, a compound of formula IIL, a compound of formula IIM, a compound of formula IIN, a compound of formula IIO, a compound of formula IIP, a compound of formula IIQ,
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Abstract
Methods for treating and preventing obesity, inhibiting adipocyte differentiation, inhibiting increased SCD-1 gene transcription, and/or reducing body fat in a subject include administering at least one analog of 1α,25-dihydroxyvitamin D3 or 1α,25-dihydroxyvitamin D2 or a pharmaceutical composition that includes such an analog to a subject in need thereof. The analog may be a 19-nor vitamin D analog such as a compound of formula IA, a compound of formula IB, or a mixture thereof where the variables R1, R2, and R3 have the values described herein.
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Citations
14 Claims
- 1. A method for inhibiting adipocyte differentiation, inhibiting SCD-1 gene transcription, and/or reducing body fat in an animal subject in need thereof, comprising administering to the animal subject, an effective amount of a 19-nor vitamin D compound or a pharmaceutical composition comprising the compound, wherein the compound administered to the subject inhibits adipocyte differentiation, inhibits SCD-1 gene transcription, and/or reduces body fat in the animal subject, and further wherein the compound is selected from a compound of formula IID, a compound of formula IIE, a compound of formula IIF, a compound of formula IIG, a compound of formula IIH, a compound of formula IIJ, a compound of formula IIK, a compound of formula IIL, a compound of formula IIM, a compound of formula IIN, a compound of formula IIO, a compound of formula IIP, a compound of formula IIQ,
Specification