Compositions, synthesis, and methods of utilizing arylpiperazine derivatives

• US 8,188,076 B2
• Filed: 02/26/2010
• Issued: 05/29/2012
• Est. Priority Date: 02/26/2009
• Status: Active Grant

• Current Assignee: Reviva Pharmaceuticals, Inc.
• Original Assignee: Reviva Pharmaceuticals, Inc.
• Inventors: Bhat, Laxminarayan, Mohapatra, Prabhu Prasad, Adiey, Kouacou
• Primary Examiner(s): Habte, Kahsay T
• Application Number:
  US12/714,406
• Publication Number:
  US 20100216783A1
• Time in Patent Office: 823 Days
• Field of Search: 544/105, 514/230.5
• US Class Current: 514/230.5
• CPC Class Codes: A61K 31/538 ortho- or peri-condensed with carbocyclic ring systems
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/18 Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: C07D 265/36 condensed with one six-membered ring
• CPC Class Codes: C07D 413/12 linked by a chain containing hetero atoms as chain links

Abstract

The present invention provides arylpiperazine derivatives having Formula I which can be advantageously used for treating schizophrenia and related psychoses such as acute manic, bipolar disorder, autistic disorder and depression.

Claims

1. A compound having the structure of Compound 14b, or a pharmaceutically acceptable salt thereof:

2. The compound of claim 1, wherein the compound is in the form of a hydrochloride salt.

4. A pharmaceutical composition comprising the compound according to claim 1 and a pharmaceutically acceptable carrier, excipient, or diluent.

5. A method of treating psychoses, schizophrenia, acute mania, bipolar disorder, autistic disorder or depression, the method comprising administering to a patient in need thereof the pharmaceutical formulation according to claim 4.

6. The method of claim 5, wherein said method treats schizophrenia.

7. The method of claim 5, wherein said method treats bipolar disorder.

3. A compound having the structure of Compound 14b, or a pharmaceutically acceptable salt or isomer thereof: