Polymorphous form of 5-chloro-N-({(5S)-2-oxo-3[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidine-5-yl}-methyl)-2-thiophene carboxamide

• US 8,188,270 B2
• Filed: 09/22/2006
• Issued: 05/29/2012
• Est. Priority Date: 10/04/2005
• Status: Active Grant

• Current Assignee: Bayer Intellectual Property GmbH (Bayer AG)
• Original Assignee: Bayer Schering Pharma AG (Bayer AG)
• Inventors: Grunenberg, Alfons, Lenz, Jana, Thomas, Christian R., Braun, Gerhard Arnold, Keil, Birgit
• Primary Examiner(s): THOMAS, TIMOTHY P
• Application Number:
  US12/089,095
• Publication Number:
  US 20100152189A1
• Time in Patent Office: 2,076 Days
• Field of Search: 544/137, 514/230.8
• US Class Current: 544/137
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C07D 413/14 containing three or more hetero rings

Abstract

The present invention relates to a novel polymorphic form and the amorphous form of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)-phenyl]-1,3-oxazolidin-5-yl}-methyl)-2-thiophene-carboxamide, processes for their preparation, medicaments comprising these forms, and their use in the control of diseases.

Claims

1. A compound of the formula (I)

2. A process for preparing a medicament comprising combining the compound of claim 1 with an inert, nontoxic, pharmaceutically suitable excipient.

3. A medicament comprising the compound of claim 1 and an inert, nontoxic, pharmaceutically suitable excipient.

4. A medicament comprising the compound of claim 1 in combination with a further active substance.

5. The medicament of claim 4, wherein the further active substance is a lipid-lowering agent, a coronary therapeutics/vasodilator, a plasminogen activator, an anticoagulant, a substance that inhibits platelet aggregation, or a fibrinogen receptor antagonist.