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Signal enhancement using a switchable magnetic trap

  • US 8,189,186 B2
  • Filed: 12/27/2007
  • Issued: 05/29/2012
  • Est. Priority Date: 12/27/2007
  • Status: Expired due to Fees
First Claim
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1. An apparatus for analysis of a sample, comprising:

  • a microchip,a microchannel flow channel in said microchip,a connecting channel connected to said microchannel flow channel,a source of magnetic particles that produces magnetic particles, said source of magnetic particles connected to said connecting channel wherein said source of magnetic particles delivers said magnetic particles to said connecting channel,a source of carrier fluid connected to said connecting channel for moving the sample in said connecting channel,a source of the sample connected to said connecting channel,fluorescent probes associated with said magnetic particles, said carrier fluid, and said sample,a source of microchannel flow channel carrier fluid connected to said microchannel flow channel wherein said microchannel flow channel carrier fluid is positioned to move the sample, said magnetic particles, and said fluorescent probes from said connecting channel into said microchannel flow channel and to move the sample, said magnetic particles, and said fluorescent probes in the microchannel flow channel,an electromagnet trap connected to said microchannel flow channel for selectively magnetically trapping the sample, said magnetic particles, and said fluorescent probes, andan analyzer positioned at or proximate said electromagnet trap for detecting said fluorescent probes and analyzing the sample.

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