Medical devices for the detection, prevention and/or treatment of neurological disorders, and methods related thereto

• US 8,190,248 B2
• Filed: 10/17/2005
• Issued: 05/29/2012
• Est. Priority Date: 10/16/2003
• Status: Active Grant

• Current Assignee: Board of Supervisors of Louisiana State University Agricultural & Mechanical College (Louisiana State University System), Louisiana Tech University Foundation (Louisiana Tech University)
• Original Assignee: Board of Supervisors of Louisiana State University Agricultural & Mechanical College (Louisiana State University System), Louisiana Tech University Foundation (Louisiana Tech University)
• Inventors: Besio, Walter G., Fasiuddin, Mohammed, Patwardhan, Ravish
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US11/252,043
• Publication Number:
  US 20060173510A1
• Time in Patent Office: 2,416 Days
• Field of Search: 607/45, 607/67, 607/139, 607/148, 600/393, 600544-545
• US Class Current: 600/544
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/165 Evaluating the state of mind, e.g. depression, anxiety
• CPC Class Codes: A61B 5/375 using biofeedback
• CPC Class Codes: A61B 5/4094 Diagnosing or monitoring seizure diseases, e.g. epilepsy
• CPC Class Codes: A61B 5/6843 Monitoring or controlling sensor contact pressure
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0536 Preventing neurodegenerative response or inflammatory reaction
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition

Abstract

Disclosed are devices and methods for detecting, preventing, and/or treating neurological disorders. These devices and methods utilize electrical stimulation, and comprise a unique concentric ring electrode component. The disclosed methods involve the positioning of multiple electrodes on the scalp of a mammal; monitoring the mammal'"'"'s brain electrical patterns to identify the onset of a neurological event; identifying the location of the brain electrical patterns indicative of neurological event; and applying transcutaneous or transcranial electrical stimulation to the location of the neurological event to beneficially modify brain electrical patterns. The disclosed methods may be useful in the detection, prevention, and/or treatment of a variety of indications, such as epilepsy, Parkinson'"'"'s Disease, Huntington'"'"'s disease, Alzheimer'"'"'s disease, depression, bipolar disorder, phobia, schizophrenia, multiple personality disorder, migraine or headache, concussion, attention deficit hyperactivity disorder, eating disorder, substance abuse, and anxiety. The disclosed methods may also be used in combination with other peripheral stimulation techniques.

Claims

1. A method of detecting brain electrical patterns indicative of a neurological event comprising

a) positioning at least two electrodes on the scalp or between the scalp and the cranium of a mammal;

b) monitoring with said at least two electrodes patterns of brain electrical patterns of the mammal'"'"'s brain to identify the presence or onset of a neurological event;

c) identifying the location of the brain electrical patterns indicative of a neurological event;

wherein each of said at least two electrodes have at least two poles comprising conductive elements configured concentrically and wherein each of said at least two electrodes is positioned wholly outside the cranium.

2. A method to modify brain electrical patterns indicative of a neurological event comprising

a) positioning at least two electrodes on the scalp or between the scalp and the cranium of a mammal;

b) monitoring with said at least two electrodes patterns of brain electrical patterns of the mammal'"'"'s brain to identify the presence or onset of a neurological event;

c) identifying the location of the brain electrical patterns indicative of a neurological event;

d) applying electrical stimulation to beneficially modify said brain electrical patterns;

wherein the stimulation is applied from at least one of said at least two electrodes;

wherein each of said at least two electrodes have at least two poles comprising conductive elements configured concentrically; and

wherein each of said at least two electrodes is positioned wholly outside the cranium.

3. The method of claim 2, wherein the electrical stimulation is applied in the form of sustained current, pulsed current, specific pulse pattern, sustained voltage, pulsed voltage, or any combination thereof.

4. The method of claim 2, wherein the electrical stimulation is applied at a frequency in the range of from about 0.1 Hz to about 2500 Hz, a pulse width in the range of from about 10 μ

sec to about 10 sec, and for a duration of from about 15 sec to about 30 min.

5. The method of claim 2, wherein the electrical stimulation is applied at a frequency in the range of from about 10 Hz to about 250 Hz, a pulse width in the range of from about 50 μ

sec to about 250 qsec, and for a duration of from about 30 sec to about 5 min.

6. The method of claim 2, wherein the electrical stimulation is applied at a voltage in the range of from about 500 mV to about 2 kV, or current in the range of from about 0.01 mA to about 1000 mA.

7. The method of claim 2, the electrical stimulation is applied at a voltage in the range of from about 30 V to about 100 V, or current in the range of from about 5 mA to about 75 mA.

8. The method of claim 2, wherein the neurological event is associated with a disease selected from the group consisting of epilepsy, Parkinson'"'"'s Disease, Huntington'"'"'s disease, Alzheimer'"'"'s disease, Pick'"'"'s disease, Parkinsonism, rigidity, hemiballism, choreoathetosis, dystonia, akinesia, bradykinesia, hyperkinesia, depression, bipolar disorder, anxiety, phobia, schizophrenia, multiple personality disorder, substance abuse, attention deficit hyperactivity disorder, eating disorder, impaired control of aggression, impaired control of sexual behavior, headache, migraine, concussion, post-concussive syndrome, and stress-related disorder.

9. The method of claim 8, wherein said neurological event is associated with epilepsy.

10. The method of claim 9, wherein said neurological event is indicative of the onset of a seizure.

11. The method of claim 2 wherein said monitoring is with five or nine electrodes.

12. The method of claim 2, wherein said at least one electrode is positioned on the scalp.

13. The method of claim 2, wherein said at least one electrode is positioned below the scalp but outside the cranium.

14. The method of claim 2, wherein at least one electrode has at least three poles comprising conductive elements configured concentrically.

15. The method of claim 14, wherein at least one electrode consists of three poles comprising conductive elements configured concentrically.

16. The method of claim 14, wherein the gap between the conductive elements configured concentrically is approximately equal to the width of the conductive elements.