Fitting a neural prosthesis using impedance and electrode height

• US 8,190,267 B2
• Filed: 10/26/2007
• Issued: 05/29/2012
• Est. Priority Date: 12/01/2005
• Status: Active Grant

• Current Assignee: Cortigent Incorporated, Doheny Eye Institute
• Original Assignee: Second Sight Medical Products, Inc. (Vivani Medical, Inc.)
• Inventors: Greenberg, Robert J., Fine, Ione, Roy, Arup, McMahon, Matthew J., Humayun, Mark S., Weiland, James David, Horsager, Alan M., Zhou, Dao Min, Hines, Amy, Yadav, Sumit, Dai, Rongqing
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US11/925,285
• Publication Number:
  US 20080294223A1
• Time in Patent Office: 1,677 Days
• Field of Search: 607/54
• US Class Current: 607/54
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye
• CPC Class Codes: A61N 1/37247 User interfaces, e.g. input or presentation means

Abstract

The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.

Claims

1. A method of determining proper placement of a visual neural stimulation electrode array comprising:

placing a two dimensional electrode array in proximity of a retina;

measuring impedance of at least one electrode in said electrode array;

communicating said impedance to a clinician by audible signal;

determining, by the impedance, the proper placement of the electrode array for optimal stimulation of the perception of vision wherein higher impedance indicates preferable placement; and

attaching said two dimensional electrode array to the retina.

2. The method according to claim 1, further comprising:

placing said electrode array in a plurality of locations;

measuring impedance across the electrode array in each location; and

determining, by the impedances, the best placement of the electrode array.

3. The method according to claim 1, further comprising:

measuring electrode height; and

estimating a threshold of perception based on said impedance and said electrode height.

4. The method according to claim 3, further comprising measuring retinal thickness;

and

estimating a threshold of perception based on said impedance, said electrode height and said retinal thickness.

5. The method according to claim 4, further comprising estimating a brightness response curve based on said impedance, said electrode height and said retinal thickness.

6. The method according to claim 1, further comprising estimating threshold of perception, based on said impedance for other geographically related electrodes.