Implantable medical devices with anti-microbial and biodegradable matrices
First Claim
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1. A vascular graft comprising:
- a luminal layer of ePTFE, the luminal layer is at least partially sintered;
a biodegradable polymer layer comprising a bioactive agent and at least one biodegradable polymer, the at least one biodegradable polymer comprising a hydrophilic region, at least two functional groups that will allow for cross-linking of the polymer, and a bioresorbable hydrophobic region, the bioactive agent controllably releases from the biodegradable polymer layer to the site of implantation of the graft, the biodegradable polymer layer being posited on the external surface of the luminal layer; and
a fabric layer posited on the external surface of said biodegradable polymer layer;
wherein said at least partially sintered luminal layer and said heat-set fabric layer are bonded together via cross-linking of said biodegradable polymer layer.
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Abstract
A composite vascular graft is provided, which incorporates bioactive agents that can be controllably delivered to the implantation site to deliver therapeutic materials and/or to reduce infection of the implant. The vascular graft of the present invention includes a luminal layer of ePTFE; and a biodegradable polymer layer including a bioactive agent, such as an antimicrobial agent. The biodegradable polymer layer is posited on the external surface of the luminal ePTFE layer. The graft also includes a fabric layer, which is posited on the external surface of the biodegradable layer. The graft is particularly useful as an arterial-venous graft for hemodialysis procedures.
109 Citations
20 Claims
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1. A vascular graft comprising:
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a luminal layer of ePTFE, the luminal layer is at least partially sintered; a biodegradable polymer layer comprising a bioactive agent and at least one biodegradable polymer, the at least one biodegradable polymer comprising a hydrophilic region, at least two functional groups that will allow for cross-linking of the polymer, and a bioresorbable hydrophobic region, the bioactive agent controllably releases from the biodegradable polymer layer to the site of implantation of the graft, the biodegradable polymer layer being posited on the external surface of the luminal layer; and a fabric layer posited on the external surface of said biodegradable polymer layer; wherein said at least partially sintered luminal layer and said heat-set fabric layer are bonded together via cross-linking of said biodegradable polymer layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification