Tissue engineering in Vivo with vascularized scaffolds

• US 8,192,487 B2
• Filed: 11/12/2010
• Issued: 06/05/2012
• Est. Priority Date: 10/13/2006
• Status: Expired due to Fees

• Current Assignee: Biostruxs LLC
• Original Assignee: Biostruxs LLC
• Inventors: Brooks, Mai Nguyen, Watson, James P
• Primary Examiner(s): Noble, Marcia S
• Application Number:
  US12/945,618
• Publication Number:
  US 20110106250A1
• Time in Patent Office: 571 Days
• Field of Search: 623/8, 424/423
• US Class Current: 623/8
• CPC Class Codes: A61K 35/12 Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells vaccines or medicinal preparations containing antigens or antibodies A61K39/00
• CPC Class Codes: C12N 2533/40 Polyhydroxyacids, e.g. polymers of glycolic or lactic acid (PGA, PLA, PLGA); Bioresorbable polymers
• CPC Class Codes: C12N 5/0653 Adipocytes; Adipose tissue

Abstract

The field of the present invention relates to a novel method for producing tissue or organ in a mammal by implanting in vivo a novel three dimensional biodegradable scaffold. The novel three dimensional biodegradable scaffolds overcome the barrier of developing large organs with tissue engineering.

Claims

1. A pair of breast implants comprising:

two growth chambers, each growth chamber having the shape of a breast;

each chamber containing therein a combination of omentum and harvested fat tissue or cells

and a blood supply connected to the omentum in each chamber

wherein each chamber is sized and shaped for placement in a breast of a patient.

2. A pair of breast implants according to claim 1, wherein said growth chambers are resorbable.

3. A pair of breast implants according to claim 1, wherein said growth chambers are comprised of a polymer.

4. A pair of breast implants according to claim 1, wherein said omentum comprises two split sections of omentum, one for each chamber.

5. A pair of breast implants according to claim 1, further comprising each chamber having at least one port.

6. A pair of breast implants according to claim 5, wherein said at least one port is connected to a source of growth media infusion.

7. A method of growing a pair of breast implants comprising:

providing two growth chambers;

placing said two growth chambers between the posterior rectus sheath and the anterior parietal peritoneum of a patient;

splitting the omentum of said patient into two separate sections, each section having its own blood supply;

placing one of said sections of omentum into the one of said growth chambers and the other of said sections of omentum into the other of said growth chambers;

adding autologous fat tissue into said omentum to grow in said growth chambers, and

placing said growth chambers in a breast of said patient following growth of fat tissue in said growth chambers while maintaining a blood supply to said omentum.

8. A method as set forth in claim 7, wherein the blood supply to said omentum is constituted by gastroepiploic blood vessels.

9. A method as set forth in claim 7, wherein said blood supply to said omentum is constituted by the axilla.

10. A method as set forth in claim 7, further comprising allowing each of said growth chambers to resorb.

11. A method as set forth in claim 7, further comprising mixing a nutrient containing matrix with said omentum during placing of said omentum sections.

12. A method as set forth in claim 7, further comprising mixing the autologous fat tissue with a nutrient containing matrix before adding the autologous fat tissue into said omentum.

13. A method as set forth in claim 12, wherein the autologous fat tissue and nutrient containing matrix mix with the omentum after being added to the omentum.

14. A method as set forth in claim 7, wherein the growth of tissue in each of said growth chambers is monitored.

15. A method as set forth in claim 7, further comprising determining that said growth chambers are each full of tissue.

16. A method as set forth in claim 7, further comprising providing growth media to each of said two growth chambers.