Polymer compositions with bioactive agent, medical articles, and methods
First Claim
Patent Images
1. A method of making a polymer composition, wherein the method comprises:
- combining a dispersion comprising hydrophilic organic microparticles with water and a metal compound under conditions effective to distribute substantially all of the metal compound within the hydrophilic organic microparticles, wherein the metal compound is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof;
wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water;
adding a hydroxide source to convert the metal compound to the corresponding metal oxide within the hydrophilic organic microparticles;
wherein the resulting metal oxide is in the form of particles having an average particle size of less than 1 micron;
optionally adding a secondary organic polymer to the dispersion; and
optionally removing a substantial portion of the water.
0 Assignments
0 Petitions
Accused Products
Abstract
A polymer composition that includes a hydrophilic polymer, an optional secondary organic polymer, and a bioactive agent distributed therein, wherein the bioactive agent is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof.
150 Citations
27 Claims
-
1. A method of making a polymer composition, wherein the method comprises:
-
combining a dispersion comprising hydrophilic organic microparticles with water and a metal compound under conditions effective to distribute substantially all of the metal compound within the hydrophilic organic microparticles, wherein the metal compound is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof;
wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water;adding a hydroxide source to convert the metal compound to the corresponding metal oxide within the hydrophilic organic microparticles;
wherein the resulting metal oxide is in the form of particles having an average particle size of less than 1 micron;optionally adding a secondary organic polymer to the dispersion; and optionally removing a substantial portion of the water. - View Dependent Claims (2, 3, 4, 5, 6)
-
-
7. A method of making a polymer composition, wherein the method comprises:
-
combining monomers for a hydrophilic organic polymer with a metal compound under conditions effective to polymerize the monomers and distribute substantially all of the metal compound within the hydrophilic organic polymer, wherein the metal compound is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof;
wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water;adding a hydroxide source to convert the bioactive agent to the corresponding metal oxide within the hydrophilic organic polymer;
wherein the resulting metal oxide is in the form of particles having an average particle size of less than 1 micron; andoptionally adding a secondary organic polymer to the hydrophilic organic polymer wherein the monomers for a hydrophilic organic polymer are dispersed in a hydrophobic liquid. - View Dependent Claims (8, 9)
-
-
10. A method of forming silver oxide in a hydrocolloid, the method comprising:
-
providing a mixture of a hydrocolloid and a solution of a silver compound with a solubility of at least 0.1 gram per liter in water;
wherein the hydrocolloid comprises hydrophilic particles;adding a hydroxide source under conditions sufficient to convert the silver compound to a metal oxide of silver (I) and disperse the silver oxide within the hydrophilic particles of the hydrocolloid;
wherein the resulting silver oxide is in the form of particles having an average particle size of less than 1 micron. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17)
-
-
18. A method of making a polymer composition comprising:
-
combining; a hydrophilic organic polymer dispersed within a hydrophobic liquid; a metal compound selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof, wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water; and a hydroxide source that converts the metal compound to the corresponding metal oxide; and dispersing the metal oxide within the hydrophilic organic polymer, which is dispersed within a hydrophobic liquid;
wherein the resulting dispersed metal oxide is in the form of particles having an average particle size of less than 1 micron.
-
-
19. A method of making a polymer composition comprising:
-
combining; a hydrophilic organic polymer dispersed within a hydrophobic liquid; a metal compound selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof, wherein the silver compound has a solubility in water of at least 0.1 gram per liter in water; water in an amount of 1 to 20 wt % based on the total weight of the polymer composition; and a hydroxide source that converts the metal compound to the corresponding metal oxide; and providing conditions effective to convert the metal compound to the corresponding metal oxide and disperse the metal oxide within the hydrophilic organic polymer, which is dispersed within a hydrophobic liquid;
wherein the resulting dispersed metal oxide is in the form of particles having an average particle size of less than 1 micron. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27)
-
Specification