Polymer-encapsulated reverse micelles
First Claim
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1. Nanoparticles comprising reverse micelles encapsulating a hydrophilic nucleic acid or protein molecule, wherein the reverse micelles are encapsulated within a hydrophobic polymeric matrix.
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Abstract
A method for encapsulating nucleic acids, particularly siRNAs, shRNAs, microRNAs, gene therapy plasmids, and other oligonucleotides in biodegradable polymers is disclosed, whereby the nucleic acids are formulated into reverse micelles composed of non-toxic and/or naturally-occurring lipids prior to nanoparticle formation by nanoprecipitation. This method can be coupled to other techniques that improve intracellular drug targeting, ultimately enhancing intracellular delivery of the aforementioned nucleic acids.
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25 Claims
- 1. Nanoparticles comprising reverse micelles encapsulating a hydrophilic nucleic acid or protein molecule, wherein the reverse micelles are encapsulated within a hydrophobic polymeric matrix.
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