Sample analyzer

• US 8,194,235 B2
• Filed: 07/28/2009
• Issued: 06/05/2012
• Est. Priority Date: 08/01/2008
• Status: Active Grant

• Current Assignee: Sysmex Corporation
• Original Assignee: Sysmex Corporation
• Inventors: Kosaka, Tokihiro, Okubo, Koichi
• Primary Examiner(s): STAFIRA, MICHAEL PATRICK
• Application Number:
  US12/462,118
• Publication Number:
  US 20100066996A1
• Time in Patent Office: 1,043 Days
• Field of Search: 356 39- 42
• US Class Current: 356/39
• CPC Class Codes: G01F 23/292 Light , e.g. infrared or ultraviolet
• CPC Class Codes: G01N 35/00584 Control arrangements for automatic analysers
• CPC Class Codes: G01N 35/1016 Control of the volume dispensed or introduced

Abstract

The present invention is to present a sample analyzer, comprising: an imaging device for imaging a sample container which has translucency and contains a sample; a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample; a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device; a sample volume obtainer for obtaining sample volume information relating to volume of the sample in the sample container, based on an image obtained by imaging the sample container by the imaging device; and a transport controller for controlling the transporting device to perform a transport operation in accordance with the sample volume information obtained by the sample volume obtainer.

Claims

1. A sample analyzer, comprising:

an imaging device for imaging a sample container which has translucency and contains a sample;

a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample;

a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device, wherein the transporting device is capable of transporting the sample container in a transport path which includes the supply position; and

a controller for performing operations comprising

obtaining sample volume information relating to volume of the sample in the sample container, based on an image obtained by imaging the sample container by the imaging device,

obtaining sample volume information relating to necessary volume of the sample for the measurement by the measuring device, and

performing a first transport control operation for controlling the transporting device so as to transport the sample container via the supply position such that the sample in the sample container is supplied to the measuring device when the volume of the sample in the sample container and the necessary volume of the sample are in a first relationship, and performing a second transport control operation for controlling the transporting device so as to transport the sample container via the supply position such that the sample in the sample container is not supplied to the measuring device when the volume of the sample in the sample container and the necessary volume of the sample are in a second relationship different from the first relationship.

2. The sample analyzer of claim 1, wherein the transporting device transports the sample container which contains a first volume of the sample when the first transport control operation is performed, and the transporting device transports the sample container which contains a second volume of the sample, the second volume being smaller than the first volume, when the second transport control operation is performed.

3. The sample analyzer of claim 1, wherein the transporting device stops the sample container at the supply position for a first time when the first transport control operation is performed, and the transport device stops the sample container at the supply position for a second time shorter than the first time when the second transport control operation is performed.

4. The sample analyzer of claim 1, wherein the transporting device stops the sample container at the supply position when the first transport control operation is performed, and the transport device does not stop the sample container at the supply position when the second transport control operation is performed.

5. The sample analyzer of claim 1, wherein the controller obtains measuring order information including a measuring item of the sample, and obtains the sample volume information relating to the necessary volume of the sample, based on the measuring order information.

6. The sample analyzer of claim 5,

wherein the measuring order information includes a plurality of measuring items of the sample;

and wherein the controller performs operations comprising;

selecting a measuring item which is a measurement execution object by the measuring device from the plurality of measuring items, based on a measuring item included in the measuring order information and the sample volume information relating to the volume of the sample in the sample container; and

controlling the measuring device so as to aspirate the sample in the sample container by a volume according to the selected measuring item.

7. The sample analyzer of claim 1, wherein:

the controller performs operations comprising;

obtaining remaining volume information relating to remaining volume of the sample contained in the sample container after the measurement of the sample by the measuring device; and

determining whether the sample is able to be re-measured based on the remaining volume information.

8. The sample analyzer of claim 1, further comprising

a sample processing device for performing a process, different from the measurement by the measuring device, to the sample contained in the sample container, wherein

the controller performs operations comprising:

obtaining remaining volume information relating to remaining volume of the sample contained in the sample container after the measurement of sample by the measuring section; and

determining whether the process of the sample by the sample processing device is possible based on the remaining volume information.

10. The sample analyzer of claim 1, wherein the controller detects a width of the sample container in the image, a position of a bottom portion of the sample container in the image and a position of a liquid surface of the sample in the image, and obtains the sample volume information based on the detection results.

11. The sample analyzer of claim 10, wherein the image includes information relating to color components of blue, green and red for each pixel;

and the controller detects the width of the sample container in the image and the position of the bottom portion of the sample container in the image based on information relating to a color component of blue or green in the image, and detects the position of the liquid surface of the sample in the image based on information relating to a color component of red in the image.

12. The sample analyzer of claim 10, wherein a bar-code label is adhered to the sample container;

and the controller detects the position of the liquid surface of the sample in the sample container, based on an image of an area excluding the bar-code label in the image.

13. The sample analyzer of claim 10, wherein the sample is a blood sample;

and the controller performs operations comprising;

determining whether a blood plasma portion and a blood cell portion of the blood sample in the sample container are separated based on the image; and

detecting the position of the liquid surface of the blood sample by performing a first liquid surface position detecting process when it is determined that the blood plasma portion and the blood cell portion of the blood sample are separated, and detecting the position of the liquid surface of the blood sample by performing a second liquid surface position detecting process different from the first liquid surface position detecting process, when it is determined that the blood plasma portion and the blood cell portion of the blood sample are not separated.

14. The sample analyzer of claim 1, wherein the transporting device is configured to transport a rack holding a plurality of sample containers such that the plurality of sample containers are sequentially transported to the supply position one by one.

15. The sample analyzer of claim 14, wherein the transport controller controls the transporting device so as to transport the rack to the supply position after the imaging device has imaged all the sample containers held by the rack.

16. The sample analyzer of claim 1, further comprising

an identification information reading device for reading identification information of the sample container, wherein the imaging device images the sample container after the identification information reading device has read the identification information of the sample container.

9. A sample analyzer, comprising

an imaging device for imaging a sample container which has translucency and contains a sample;

a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample;

a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device, wherein the transporting device is capable of transporting the sample container in a first transport path for transporting the sample container to the supply position and a second transport path for not transporting the sample container to the supply position; and

a controller for performing operations comprising

obtaining sample volume information relating to volume of the sample in the sample container, based on an image obtained by imaging the sample container by the imaging device,

obtaining sample volume information relating to necessary volume of the sample for the measurement by the measuring device; and

performing a first transport control operation for controlling the transporting device so as to transport the sample container in the first transport path when the volume of the sample in the sample container and the necessary volume of the sample are in a first relationship, and performing a second transport control operation for controlling the transporting device so as to transport the sample container in the second transport path when the volume of the sample in the sample container and the necessary volume of the sample are in a second relationship different from the first relationship.

17. A sample analyzer, comprising:

an imaging device for imaging a sample container which has translucency and contains a sample;

a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample;

a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device; and

a controller for performing operations comprising

obtaining sample volume information relating to volume of the sample in the sample container, based on an image obtained by imaging the sample container by the imaging device;

obtaining sample volume information relating to necessary volume of the sample for the measurement by the measuring device, and

controlling the measuring device so as to perform an aspirating operation for aspirating the sample contained in the sample container when the volume of the sample in the sample container is equal to or larger than the necessary volume of the sample, and controlling the measuring device so as not to perform the aspirating operation when the volume of the sample in the sample container is smaller than the necessary volume of the sample.

18. The sample analyzer of claim 17, wherein

the controller detects a width of the sample container in the image, a position of a bottom portion of the sample container in the image and a position of a liquid surface of the sample in the image, and obtains the sample volume information based on the detection results.

19. A sample analyzer, comprising:

a volume information obtaining device for obtaining sample volume information relating to volume of a sample contained in a sample container;

a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample;

a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device, wherein the transporting device is capable of transporting the sample container in a transport path which includes the supply position; and

a controller for performing operations comprising

obtaining sample volume information relating to necessary volume of the sample for the measurement by the measuring device, and

performing a first transport control operation for controlling the transporting device so as to transport the sample container via the supply position such that the sample in the sample container is supplied to the measuring device when the volume of the sample in the sample container and the necessary volume of the sample are in a first relationship, and performing a second transport control operation for controlling the transporting device so as to transport the sample container via the supply position such that the sample in the sample container is not supplied to the measuring device when the volume of the sample in the sample container and the necessary volume of the sample are in a second relationship different from the first relationship.

20. A sample analyzer, comprising

a volume information obtaining device for obtaining sample volume information relating to volume of a sample contained in a sample container;

a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample;

a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device, wherein the transporting device is capable of transporting the sample container in a first transport path for transporting the sample container to the supply position and a second transport path for not transporting the sample container to the supply position; and

a controller for performing operations comprising

obtaining sample volume information relating to necessary volume of the sample for the measurement by the measuring device; and

performing a first transport control operation for controlling the transporting device so as to transport the sample container in the first transport path when the volume of the sample in the sample container and the necessary volume of the sample are in a first relationship, and performing a second transport control operation for controlling the transporting device so as to transport the sample container in the second transport path when the volume of the sample in the sample container and the necessary volume of the sample are in a second relationship different from the first relationship.

21. A sample analyzer, comprising:

a volume information obtaining device for obtaining sample volume information relating to volume of a sample contained in a sample container;

a measuring device for aspirating the sample contained in the sample container and measuring the aspirated sample;

a transporting device for transporting the sample container to a supply position for supplying the sample contained in the sample container to the measuring device; and

a controller for performing operations comprising

obtaining sample volume information relating to a necessary volume of the sample for the measurement by the measuring device, and

controlling the measuring device so as to perform an aspirating operation for aspirating the sample contained in the sample container when the volume of the sample in the sample container is equal to or larger than the necessary volume of the sample, and controlling the measuring device so as not to perform the aspirating operation when the volume of the sample in the sample container is smaller than the necessary volume of the sample.