Solution sample plate with wells designed for improved Raman scattering signal detection efficiency
First Claim
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1. A sample plate comprising:
- one or more sample containers for holding test samples; and
a visible spectrum optical reflective material coating at least a part of the sample container,wherein the visible spectrum optical reflective material enhances visible light signal reflectivity in relative to a sample plate without the visible spectrum optical reflective material coating,wherein the one or more sample containers for holding test samples are configured to hold a liquid, and wherein bottoms of the one or more sample containers have a rounded surface having a single point of maximum focus.
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Abstract
Devices, methods of using the device, systems including the device that include a sample plate with sample containers (wells), wherein at least a portion of the surface of the sample plate and/or sample containers is coated with an optical reflective material. The optical reflective material, provides enhanced excitation signal intensity and enhanced Raman signal intensity. Such enhancement provides improved total signal detection capabilities, and methods of improved focusing algorithms.
50 Citations
36 Claims
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1. A sample plate comprising:
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one or more sample containers for holding test samples; and a visible spectrum optical reflective material coating at least a part of the sample container, wherein the visible spectrum optical reflective material enhances visible light signal reflectivity in relative to a sample plate without the visible spectrum optical reflective material coating, wherein the one or more sample containers for holding test samples are configured to hold a liquid, and wherein bottoms of the one or more sample containers have a rounded surface having a single point of maximum focus. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 29)
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13. A method of enhancing Raman signal and excitation light comprising:
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obtaining a sample plate having one or more sample containers, wherein the bottoms of the one or more sample containers have a rounded surface having a single point of maximum focus; coating a portion of the sample container with a visible spectrum optical reflective material; exposing the sample container to excitation light of a desired wavelength, the excitation light causing Raman scattering; and detecting a light signal emanating from the sample container. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 30, 31, 32, 33, 35)
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21. A system comprising:
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a sample plate having one or more sample containers, wherein the at least a portion of the sample container includes a coating of a visible spectrum optical reflective material, wherein the visible spectrum optical reflective material comprises a metals selected from the group consisting of gold, silver, aluminum, and combinations thereof, and wherein bottoms of the one or more sample containers have a rounded surface having a single point of maximum focus; a sample to be evaluated; an excitation light source; and a detection device capable of detecting reflected excitation and Raman light signal. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 34, 36)
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Specification