Controlled titration of neurostimulation therapy
First Claim
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1. An implantable device for delivering neurostimulation, comprising:
- a pulse generator for outputting neural stimulation pulses to one or more stimulation electrodes connected to the pulse generator for delivering electrical stimulation to a selected neural site;
a controller connected to the pulse generator for controlling the output of neural stimulation pulses in accordance with a defined schedule and in accordance with specified stimulation parameters;
a telemetry unit interfaced to the controller for enabling user input of a defined schedule for delivering neurostimulation and specified stimulation parameters;
one or more sensing modalities for sensing a physiological variable reflective of a patient'"'"'s autonomic balance; and
,wherein the controller is programmed to adjust the amount of neurostimulation delivered in accordance with a determination of the patient'"'"'s autonomic balance and further programmed to receive medication dosage information via telemetry and modify the schedule for delivering neurostimulation accordingly.
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Abstract
Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient'"'"'s autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient'"'"'s autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
111 Citations
20 Claims
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1. An implantable device for delivering neurostimulation, comprising:
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a pulse generator for outputting neural stimulation pulses to one or more stimulation electrodes connected to the pulse generator for delivering electrical stimulation to a selected neural site; a controller connected to the pulse generator for controlling the output of neural stimulation pulses in accordance with a defined schedule and in accordance with specified stimulation parameters; a telemetry unit interfaced to the controller for enabling user input of a defined schedule for delivering neurostimulation and specified stimulation parameters; one or more sensing modalities for sensing a physiological variable reflective of a patient'"'"'s autonomic balance; and
,wherein the controller is programmed to adjust the amount of neurostimulation delivered in accordance with a determination of the patient'"'"'s autonomic balance and further programmed to receive medication dosage information via telemetry and modify the schedule for delivering neurostimulation accordingly. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for operating an implantable device to deliver neurostimulation, comprising:
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outputting neural stimulation pulses to one or more stimulation electrodes connected to a pulse generator for delivering electrical stimulation to a selected neural site; controlling the output of neural stimulation pulses in accordance with a defined schedule and in accordance with specified stimulation parameters; enabling user input of a defined schedule for delivering neurostimulation and specified stimulation parameters; sensing a physiological variable reflective of a patient'"'"'s autonomic balance; and
,adjusting the amount of neurostimulation delivered in accordance with a determination of the patient'"'"'s autonomic balance and further programmed to receive medication dosage information via telemetry and modify the schedule for delivering neurostimulation accordingly. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification