Devices and methods for electrical stimulation of the diaphragm and nerves

• US 8,195,297 B2
• Filed: 10/13/2009
• Issued: 06/05/2012
• Est. Priority Date: 10/13/2008
• Status: Active Grant

• Current Assignee: E-Pacing Inc.
• Original Assignee: E-Pacing Inc.
• Inventors: Penner, Abraham
• Primary Examiner(s): GETZOW, SCOTT M
• Application Number:
  US12/578,370
• Publication Number:
  US 20100094376A1
• Time in Patent Office: 966 Days
• Field of Search: 607/2, 607/3, 607/42
• US Class Current: 607/42
• CPC Class Codes: A61B 2017/3425 for internal organs, e.g. heart ports
• CPC Class Codes: A61N 1/0517 Esophageal electrodes
• CPC Class Codes: A61N 1/0519 Endotracheal electrodes
• CPC Class Codes: A61N 1/3601 of respiratory organs

Abstract

Medical devices, systems, and methods are provided for providing respiratory therapy by electrically stimulating the phrenic nerves and/or the thoracic diaphragm. In one embodiment, at least one electrode is deployed to a position within the patient'"'"'s airway and placed in proximity to a phrenic nerve or to the diaphragm. The electrode may be attached to a controller housing including a pulse generator using one or more electrical lead or leads or may be in wireless communication with the pulse generator. The controller housing may be implanted at a position within the patient or the controller housing may reside external to the patient.

Claims

1. A method for electrically stimulating a diaphragm, comprising:

inserting a catheter into a patient'"'"'s mouth or nasal cavity;

delivering at least one electrode carried by at least one electrical lead through a lumen in the catheter;

positioning and fixing the at least one electrode at a selected position within a patient'"'"'s bronchus in operable proximity to at least one of a thoracic diaphragm or a phrenic nerve, wherein the at least one electrode and at least one electrical lead are in operable electrical communication with a pulse generator housed within a controller housing; and

delivering at least one electrical stimulation signal from the at least one electrode to at least one of the thoracic diaphragm or the phrenic nerve.

2. The method of claim 1, wherein the catheter comprises an intubation tube.

3. The method of claim 1, wherein the at least one electrode comprises at least one wireless electrode in wireless communication with the pulse generator, and wherein delivering the at least one electrical stimulation signal comprises:

wirelessly transmitting at least one command from the pulse generator to the at least one electrode;

generating the at least one electrical stimulation signal at the at least one electrode upon receiving the at least one command; and

delivering the at least one electrical stimulation signal from the at least one electrode.

4. The method of claim 3, wherein wirelessly transmitting the at least one command comprises transmitting the at least one command utilizing radio frequency communication.

5. The method of claim 3, further comprising:

sensing at least one condition associated with the patient'"'"'s respiratory activity; and

wirelessly transmitting a signal to the pulse generator containing data associated with the at least one condition from the at least one electrode.

6. The method of claim 5, further comprising:

generating at least one additional command based at least in part on the data associated with the at least one condition;

wirelessly transmitting the at least one additional command from the pulse generator to the at least one electrode; and

generating and delivering at least one additional electrical stimulation signal upon receiving the at least one additional command at the at least one electrode.

7. The method of claim 5, wherein the one or more conditions associated with the patient'"'"'s respiratory activity comprises at least one of:

(a) thoracic diaphragm movement;

(b) costal muscle movement;

or (c) lung movement.

8. The method of claim 1, wherein delivering the at least one electrical stimulation signal comprises delivering at least one electrical stimulation signal effective in diaphragmatic pacing.

9. The method of claim 1, wherein delivering the at least one electrical stimulation signal comprises delivering the at least one electrical stimulation signal to at least one of:

(a) the left side of the patient'"'"'s thoracic diaphragm;

(b) the right side of the patient'"'"'s thoracic diaphragm;

(c) the patient'"'"'s left phrenic nerve;

(d) the patient'"'"'s right phrenic nerve;

or (e) any combination thereof.

10. The method of claim 1, further comprising receiving, at the pulse generator, at least one signal indicating an operation of a mechanical ventilation system, wherein delivering the at least one electrical stimulation signal is based at least in part on the at least one signal indicating the operation of the mechanical ventilation system.

11. The method of claim 10, wherein the at least one electrical stimulation signal is effective to perform at least one of:

(a) ventilation therapy;

or (b) diaphragmatic stimulation to treat muscle atrophy.