Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
First Claim
1. A method for optimizing therapeutic stimulation parameters for a patient suffering from pain or depression using therapy electrodes that have been positioned at a target therapy site within the central nervous system, the method comprising:
- applying an electrical stimulus at a sub-threshold current intensity level relative to a threshold level for neurons at the target therapy site;
sensing a response to the electrical stimulus at a sensing device that has been positioned at a sense location of the patient;
selecting an alternate stimulus parameter while maintaining a constant electrode configuration, wherein the alternate stimulus parameter comprises decreasing the sub-threshold current intensity to a lower level;
applying the alternate stimulus parameter;
correlating a change in a sensed response to determine a stimulus/response relationship that is expected to improve efficacy according to the stimulus/response relationship;
repeating the applying, sensing, selecting and correlating procedures using the alternate stimulus parameter;
choosing the electrical stimulus corresponding to the sensed response that is within a desired range and/or provides a better result compared to other sensed responses; and
repeating (a) the decreasing the sub-threshold current intensity to a lower level, (b) re-applying decreased sub-threshold stimulus the lower current intensity to the neurons, and (c) further determining whether application of the decreased sub-threshold current intensity further decreased a membrane activation threshold for the population of neurons until the membrane activation threshold by or to a selected level.
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Abstract
Methods and devices for automatically optimizing the stimulus parameters and/or the configuration of electrodes to provide neural stimulation to a patient. In one embodiment, a system includes an electrode array having an implantable support member configured to be implanted into the patient and a plurality of therapy electrodes carried by the support member. The system can also have a pulse system operatively coupled to the therapy electrodes to deliver a stimulus to the therapy electrodes, and a sensing device configured to be attached to a sensing location of the patient. The sensing device generates response signals in response to the stimulus. The system can also include a controller operatively coupled to the pulse system and to the sensing device. The controller includes a computer operable medium that generates command signals that define the stimulus delivered by the pulse system, evaluates the response signals from the sensing device, and determines a desired configuration for the therapy electrodes and/or a desired stimulus to be delivered to the therapy electrodes.
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Citations
4 Claims
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1. A method for optimizing therapeutic stimulation parameters for a patient suffering from pain or depression using therapy electrodes that have been positioned at a target therapy site within the central nervous system, the method comprising:
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applying an electrical stimulus at a sub-threshold current intensity level relative to a threshold level for neurons at the target therapy site; sensing a response to the electrical stimulus at a sensing device that has been positioned at a sense location of the patient; selecting an alternate stimulus parameter while maintaining a constant electrode configuration, wherein the alternate stimulus parameter comprises decreasing the sub-threshold current intensity to a lower level; applying the alternate stimulus parameter; correlating a change in a sensed response to determine a stimulus/response relationship that is expected to improve efficacy according to the stimulus/response relationship; repeating the applying, sensing, selecting and correlating procedures using the alternate stimulus parameter; choosing the electrical stimulus corresponding to the sensed response that is within a desired range and/or provides a better result compared to other sensed responses; and repeating (a) the decreasing the sub-threshold current intensity to a lower level, (b) re-applying decreased sub-threshold stimulus the lower current intensity to the neurons, and (c) further determining whether application of the decreased sub-threshold current intensity further decreased a membrane activation threshold for the population of neurons until the membrane activation threshold by or to a selected level. - View Dependent Claims (2, 3, 4)
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Specification