Implantable hermetically sealed structures

• US 8,195,308 B2
• Filed: 12/22/2005
• Issued: 06/05/2012
• Est. Priority Date: 12/22/2004
• Status: Active Grant

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Frank, Jeremy, Gelfandbein, Vladimier, Jensen, Marc, Zdeblick, Mark J., Costello, Benedict James
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Malamud, Deborah
• Application Number:
  US11/794,016
• Publication Number:
  US 20080312726A1
• Time in Patent Office: 2,357 Days
• Field of Search: 607 1- 2, 607/116, 607/119, 607/122, 600/372, 600/393, 600/395
• US Class Current: 607/122
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/375 Constructional arrangements, e.g. casings
• CPC Class Codes: A61N 1/37512 Pacemakers
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Implantable hermetically sealed structures and methods for making the same. Devices, systems and kits including the hermetically sealed structures, as well as methods of using such devices and systems are included.

Claims

1. An implantable hermetically sealed structure dimensioned to be placed inside a lead, the structure comprising:

an in vivo corrosion resistant holder comprising;

a plurality of in vivo corrosion resistant walls (“

walls”

), each wall in the plurality of walls comprising a top edge, adjoining edges, and a bottom edge, each adjoining edge of each wall in the plurality of walls physically associated with a respective adjoining edge of a respective wall in the plurality of walls to form a first opening at one end and a second opening at an opposite end;

a bottom physically associated with the bottom edge of each wall in the plurality of walls to cap the first opening at one end of the in vivo corrosion resistant holder; and

at least one conductive feedthrough extending through the bottom; and

a metallic sealing layer physically associated with the top edge of each wall in the plurality of walls to substantially cap the second opening at an opposite end and to define a volume capable of accommodating an effector, whereby the metallic sealing layer, the in vivo corrosion resistant holder, and the at least one conductive feedthrough in combination are operable to hermetically seal the effector.

2. The implantable hermetically sealed structure according to claim 1, further comprising the effector.

3. The implantable hermetically sealed structure according to claim 2, wherein the effector further comprises at least one of an integrated circuit and an actuator.

4. The implantable hermetically sealed structure according to claim 3, wherein the actuator further comprises an electrode.

5. The implantable hermetically sealed structure according to claim 1, wherein the hermetically sealed structure is configured to remain hermetically sealed in a saline environment for at least 10 years.

6. The implantable hermetically sealed structure according to claim 1, wherein the in vivo corrosion resistant holder comprises at least two conductive feedthroughs.

7. The implantable hermetically sealed structure according to claim 1, wherein the conductive feedthrough is a metal.

8. The implantable hermetically sealed structure according to claim 1, wherein the corrosion resistant holder comprises silicon.

9. The implantable hermetically sealed structure according to claim 1, wherein the corrosion resistant holder is fabricated using a planar processing protocol.

10. The implantable hermetically sealed structure according to claim 1, wherein the structure further comprises an insulative material present within the opening.

11. An implantable medical device comprising a hermetically sealed structure according to claim 1.

12. The implantable medical device according to claim 11, further comprising the effector.

13. The implantable medical device according to claim 11, wherein the structure is present in a lead.

14. The implantable medical device according to claim 13, wherein the lead is a cardiovascular lead.

15. The implantable medical device according to claim 14, wherein the lead is a left ventricular lead.

16. The implantable medical device according to claim 14, wherein the lead is an epicardial lead.

17. The implantable medical device according to claim 11, wherein the structure is present in an implant.

18. The implantable medical device according to claim 17, wherein the implant is a cardiovascular implant.

19. The implantable medical device according to claim 11, wherein the device is chosen from a neurological device, a muscular device, a gastrointestinal device, a skeletal device, a pulmonary device, an ophthalmic device and an auditory device.

20. The implantable medical device according to claim 11, wherein the at least one conductive member is electrically coupled to a control unit.

21. The implantable medical device according to claim 20, wherein the control unit is present in a pacemaker can.

22. The implantable medical device according to claim 21, wherein the device is a cardiovascular pacing device.

23. The implantable medical device according to claim 11, wherein the device comprises two or more of the hermetically sealed structures.