Ultrasound guided high intensity focused ultrasound treatment of nerves

• US 8,197,409 B2
• Filed: 02/23/2009
• Issued: 06/12/2012
• Est. Priority Date: 09/17/1999
• Status: Expired due to Fees

• Current Assignee: University of Washington
• Original Assignee: University of Washington
• Inventors: Foley, Jessica L., Vaezy, Shahram, Little, James W.
• Primary Examiner(s): ROZANSKI, MICHAEL T
• Application Number:
  US12/390,975
• Publication Number:
  US 20100234728A1
• Time in Patent Office: 1,205 Days
• Field of Search: 601/2, 600/411, 600/437, 600/439
• US Class Current: 600/439
• CPC Class Codes: A61B 2017/4216 Operations on uterus, e.g. endometrium
• CPC Class Codes: A61B 2018/00434 Neural system
• CPC Class Codes: A61B 2090/378 using ultrasound
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/0816 using echo-encephalography
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4209 by using holders, e.g. positioning frames
• CPC Class Codes: A61B 8/4254 using sensors mounted on the probe
• CPC Class Codes: A61B 8/4281 characterised by sound-transmitting media or devices for coupling the transducer to the tissue
• CPC Class Codes: A61B 8/4444 related to the probe
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/483 involving the acquisition of a 3D volume of data
• CPC Class Codes: A61N 7/02 Localised ultrasound hyperthermia hyperthermia in general A61F7/00

Abstract

A method for using high intensity focused ultrasound (HIFU) to treat neurological structures to achieve a desired therapeutic effect. Depending on the dosage of HIFU applied, it can have a reversible or irreversible effect on neural structures. For example, a relatively high dose of HIFU can be used to permanently block nerve function, to provide a non-invasive alternative to severing a nerve to treat severe spasticity. Relatively lower doses of HIFU can be used to reversibly block nerve function, to alleviate pain, to achieve an anesthetic effect, or to achieve a cosmetic effect. Where sensory nerves are not necessary for voluntary function, but are involved in pain associated with tumors or bone cancer, HIFU can be used to non-invasively destroy such sensory nerves to alleviate pain without drugs. Preferably, ultrasound imaging synchronized to the HIFU therapy is used to provide real-time ultrasound image guided HIFU therapy of neural structures.

Claims

1. A method for using high intensity focused ultrasound (HIFU) to achieve a desired therapeutic effect associated with selected spinal or peripheral nerves in a patient, comprising the steps of:

(a) determining an appropriate treatment site associated with the selected spinal or peripheral nerves;

(b) selecting a dose of HIFU required to achieve the desired therapeutic effect;

(c) positioning an HIFU therapy probe external to a body, such that a focal point of the HIFU therapy probe is disposed at or adjacent to the treatment site;

(d) verifying that the focal point of the externally positioned HIFU therapy probe is properly positioned relative to the treatment site by (i) using ultrasound imaging to obtain an ultrasound image of the treatment site and (ii) energizing the HIFU therapy probe at a power level that is insufficient to induce damage at the treatment site, but is sufficient to enable the focal point of the HIFU therapy probe to be visualized in the ultrasound image, and if not, repositioning the HIFU therapy probe until the focal point of the HIFU therapy probe is properly positioned relative to the treatment site,

(e) energizing the HIFU therapy probe to provide the dose of HIFU required to achieve the desired therapeutic effect; and

(f) using ultrasound imaging to obtain an ultrasound image of the treatment site during therapy.

2. The method of claim 1, wherein step (f) of using ultrasound imaging to obtain an ultrasound image of the treatment site during therapy includes synchronizing the HIFU therapy probe and the ultrasound imaging such that noise in the ultrasound image arising from the HIFU therapy probe does not prevent visualization of the focal point in the ultrasound image during therapy.

3. The method of claim 1, wherein the desired therapeutic effect comprises blocking nerve conduction to achieve a cosmetic effect.

4. The method of claim 1, wherein the desired therapeutic effect comprises blocking nerve conduction to provide anesthesia of a nerve.

5. The method of claim 1, wherein the desired therapeutic effect comprises blocking nerve conduction to alleviate pain.

6. The method of claim 1, wherein the desired therapeutic effect comprises blocking nerve conduction to treat spasticity.

7. The method of claim 1, wherein the step of determining the appropriate treatment site comprises at least one step selected from the group consisting of

(a) the step of selecting a nerve as the treatment site;

and

(b) the step of selecting a nerve ganglia as the treatment site.

8. The method of claim 1, wherein the step of selecting the dose of HIFU required to achieve the desired therapeutic effect comprises the step of determining the dose of HIFU required to partially block nerve conduction at the treatment site.

9. The method of claim 1, wherein the step of selecting the dose of HIFU required to achieve the desired therapeutic effect comprises the step of determining the dose of HIFU required to completely block nerve conduction at the treatment site.

10. The method of claim 1, wherein the step of verifying that the focal point of the HIFU therapy probe is properly positioned relative to the treatment site comprises the steps of:

(a) positioning an ultrasound imaging device and the HIFU therapy probe such that the focal point lies within an image plane provided by the ultrasound imaging device;

(b) providing an indication of where the focal point lies within an ultrasound image generated by the ultrasound imaging device, such that the focal point can be visualized in the ultrasound image, even when the HIFU therapy probe is not energized;

(c) fixing a position of the ultrasound imaging device relative to the HIFU therapy probe, such that movement of either device will not move the focal point out of the image plane;

(d) obtaining the ultrasound image of the treatment site; and

(e) manipulating at least one of the ultrasound imaging device, the HIFU therapy probe, and a frame used to secure the position of the ultrasound imaging device relative to the HIFU therapy probe until the indication of the focal point is properly positioned relative to the treatment site.

11. The method of claim 1, wherein the appropriate treatment site determined in step (a) is a peripheral nerve adjacent to a blood vessel.