Systems and methods of modeling pharmaceutical propagation in a patient
First Claim
1. A method of modeling propagation of a pharmaceutical fluid in a patient, the method comprising the steps of:
- (a) injecting during at least one test injection the pharmaceutical fluid into the patient, the pharmaceutical fluid including at least a contrast medium;
(b) collecting data corresponding to at least one of a measurement and an estimate of a concentration of the pharmaceutical fluid in the blood of the patient, the data being indicative of a time enhancement output resulting from the injection of the pharmaceutical fluid into the patient; and
(c) determining at least one mathematical model individualized to the patient that describes the data obtained as a result of the injection of the pharmaceutical fluid into the patient.
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Abstract
An injection system includes an injector for injecting a fluid into a patient and a controller in operative communication with the injector for control thereof. The controller controls a diagnostic injection of the fluid based upon at least one mathematical model individualized to the patient. The model(s) are determined by collecting data corresponding to a time response curve resulting from at least one test injection of the fluid into the patient. The time response curve represents a response of a region of interest of the patient over time due to the fluid passing therethrough. An imaging system having such an injection system is also disclosed, as is a system for effecting a medical procedure. A method of delivering such a fluid to a patient using such an injection system is also disclosed, as is a method of modeling propagation of such a fluid in a patient.
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Citations
35 Claims
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1. A method of modeling propagation of a pharmaceutical fluid in a patient, the method comprising the steps of:
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(a) injecting during at least one test injection the pharmaceutical fluid into the patient, the pharmaceutical fluid including at least a contrast medium; (b) collecting data corresponding to at least one of a measurement and an estimate of a concentration of the pharmaceutical fluid in the blood of the patient, the data being indicative of a time enhancement output resulting from the injection of the pharmaceutical fluid into the patient; and (c) determining at least one mathematical model individualized to the patient that describes the data obtained as a result of the injection of the pharmaceutical fluid into the patient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method of controlling injection of a pharmaceutical fluid into a patient using an injector in a medical procedure, the method comprising the steps of:
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(a) collecting data corresponding to a patient response curve resulting from a test injection of the pharmaceutical fluid into the patient, the pharmaceutical fluid including at least a contrast medium; (b) determining at least one mathematical model individualized to the patient that describes the data obtained as a result of the test injection of the pharmaceutical fluid into the patient; and (c) subsequent to the test injection, controlling the injector during the medical procedure to control administration of an imaging injection of the pharmaceutical fluid into the patient to create a patient response at least in part on the basis of the at least one mathematical model determined from the data obtained as a result of the test injection of the pharmaceutical fluid into the patient. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. An injection system comprising:
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(a) an injector for injecting a fluid into a patient; and (b) a controller in operative communication with the injector to control the injector, the controller controlling a diagnostic injection of the fluid based upon at least one mathematical model individualized to the patient, the at least one mathematical model being determined by collecting data corresponding to a time enhancement curve resulting from at least one test injection of a contrast medium into the patient, the time enhancement curve representing enhancement of a desired region of interest of the patient over time due to the contrast medium passing therethrough. - View Dependent Claims (33)
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34. A system for effecting a medical procedure, the system comprising:
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(a) a sensing system to detect a patient response; (b) an injector adapted to inject a pharmaceutical fluid; and (c) a controller in operative communication with the injector to control the injector, the controller controlling a diagnostic injection of the pharmaceutical fluid based upon at least one mathematical model individualized to the patient, the at least one mathematical model being determined by collecting data from the sensing system corresponding to a time response curve resulting from a test injection of the pharmaceutical fluid into the patient, the time response curve representing a response of a desired region of interest of the patient over time to the pharmaceutical fluid passing therethrough due to the test injection thereof.
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35. An imaging system comprising:
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(a) an imager to create an image of a region of interest of a patient; (b) an injector adapted to inject a contrast medium into the patient; and (c) a controller in operative communication with the injector to control the injector, the controller controlling a diagnostic injection of the contrast medium based upon at least one mathematical model individualized to the patient, the at least one mathematical model being determined by collecting data from the imager corresponding to a time enhancement curve resulting from a test injection of the contrast medium into the patient, the time enhancement curve representing enhancement of the region of interest over time due to the contrast medium passing therethrough.
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Specification