Method for providing progressive therapy for thrombus management
First Claim
1. A method of using a plurality of expandable tip assemblies adapted to address an occlusive thrombus within a blood vessel for providing progressive therapy, the method comprising:
- identifying a thrombus within a blood vessel;
inserting an expandable reperfusion device into the blood vessel within a microcatheter to the location of the thrombus,wherein the expandable reperfusion device comprises a self-expandable reperfusion scaffold having a plurality of interconnected struts that form cells sized and configured to reduce protrusion of the thrombus within the reperfusion scaffold,wherein the self-expandable reperfusion scaffold has an open, non-filtering distal end;
deploying the self-expandable reperfusion scaffold within the thrombus by retracting the microcatheter to unsheath the reperfusion scaffold and allow the reperfusion scaffold to expand within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing one or more blood flow channels through the thrombus,wherein the one or more blood flow channels facilitate natural lysis of the thrombus;
resheathing the reperfusion scaffold within the microcatheter by advancing the microcatheter and then unsheathing the reperfusion device by retracting the microcatheter to provide maceration of the thrombus;
removing the reperfusion device;
inserting an expandable thrombus removal device into the blood vessel within the microcatheter to the location of the thrombus,wherein the expandable thrombus removal device comprises a self-expandable removal scaffold having a plurality of interconnected struts that form cells sized and configured to allow thrombus penetration within the cells, thereby facilitating engagement of the thrombus by the removal scaffold;
deploying the removal scaffold within a remaining portion of the thrombus, thereby engaging the remaining portion of the thrombus;
extracting the remaining portion of the thrombus engaged by the removal scaffold from the blood vessel; and
removing the thrombus removal device.
3 Assignments
0 Petitions
Accused Products
Abstract
Systems, methods, and devices for the treatment of acute ischemic stroke that provide immediate blood flow restoration to a vessel occluded by a clot and, after reestablishing blood flow, address the clot itself. Immediate blood flow restoration advantageously can facilitate natural lysis of the clot and also can reduce or obviate the concern for distal embolization due to fragmentation of the clot. Several embodiments of the invention provide for progressive, or modular, treatment based upon the nature of the clot. For example, the progressive treatment can comprise a three-step progressive treatment process that includes immediate restoration of blood flow, in-situ clot management, and/or clot removal depending on the particular circumstances of the treatment. The in-situ clot management can include, for example, lysis and maceration. The progressive, or modular, treatment can be provided by a system or kit of one or more treatment devices.
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Citations
24 Claims
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1. A method of using a plurality of expandable tip assemblies adapted to address an occlusive thrombus within a blood vessel for providing progressive therapy, the method comprising:
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identifying a thrombus within a blood vessel; inserting an expandable reperfusion device into the blood vessel within a microcatheter to the location of the thrombus, wherein the expandable reperfusion device comprises a self-expandable reperfusion scaffold having a plurality of interconnected struts that form cells sized and configured to reduce protrusion of the thrombus within the reperfusion scaffold, wherein the self-expandable reperfusion scaffold has an open, non-filtering distal end; deploying the self-expandable reperfusion scaffold within the thrombus by retracting the microcatheter to unsheath the reperfusion scaffold and allow the reperfusion scaffold to expand within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing one or more blood flow channels through the thrombus, wherein the one or more blood flow channels facilitate natural lysis of the thrombus; resheathing the reperfusion scaffold within the microcatheter by advancing the microcatheter and then unsheathing the reperfusion device by retracting the microcatheter to provide maceration of the thrombus; removing the reperfusion device; inserting an expandable thrombus removal device into the blood vessel within the microcatheter to the location of the thrombus, wherein the expandable thrombus removal device comprises a self-expandable removal scaffold having a plurality of interconnected struts that form cells sized and configured to allow thrombus penetration within the cells, thereby facilitating engagement of the thrombus by the removal scaffold; deploying the removal scaffold within a remaining portion of the thrombus, thereby engaging the remaining portion of the thrombus; extracting the remaining portion of the thrombus engaged by the removal scaffold from the blood vessel; and removing the thrombus removal device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of using a plurality of expandable tip assemblies adapted to address an occlusive thrombus within a blood vessel for providing progressive therapy, the method comprising:
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identifying a thrombus within a blood vessel; inserting an expandable reperfusion device into the blood vessel within a microcatheter to the location of the thrombus, wherein the expandable reperfusion device comprises a self-expandable reperfusion scaffold having a plurality of interconnected struts that form cells sized and configured to reduce protrusion of the thrombus within the reperfusion scaffold, wherein the self-expandable reperfusion scaffold has an open, non-filtering distal end; deploying the self-expandable reperfusion scaffold within the thrombus by retracting the microcatheter and allowing the reperfusion scaffold to expand within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing one or more blood flow channels through the thrombus, wherein the one or more blood flow channels facilitate natural lysis of the thrombus; macerating the thrombus with the reperfusion scaffold by sheathing and unsheathing of the reperfusion scaffold caused by advancement and retraction of the microcatheter, wherein said sheathing and unsheathing causes the reperfusion scaffold to compress and expand, thereby fragmenting, dissolving, or imploding the thrombus; removing the reperfusion device; inserting an expandable thrombus removal device into the blood vessel within a microcatheter to the location of the thrombus, wherein the expandable thrombus removal device comprises a self-expandable removal scaffold having a plurality of interconnected struts that form cells sized and configured to allow thrombus penetration within the cells, thereby facilitating engagement of the thrombus by the removal scaffold; deploying the removal scaffold within a remaining portion of the thrombus, thereby engaging the remaining portion of the thrombus; extracting the remaining portion of the thrombus engaged by the removal scaffold from the blood vessel; and removing the thrombus removal device. - View Dependent Claims (16, 17, 18, 19)
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20. A method of using a plurality of expandable tip assemblies adapted to address an occlusive thrombus within a blood vessel for providing progressive therapy, the method comprising:
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identifying a thrombus within a blood vessel; inserting an expandable reperfusion device into the blood vessel within a microcatheter to the location of the thrombus, wherein the expandable reperfusion device comprises a self-expandable reperfusion scaffold having a plurality of interconnected struts that form cells sized and configured to reduce protrusion of the thrombus within the reperfusion scaffold, wherein the self-expandable reperfusion scaffold has an open, non-filtering distal end; deploying the self-expandable reperfusion scaffold within the thrombus, thereby compressing the thrombus against the inner vessel wall and establishing one or more blood flow channels through the thrombus, wherein the one or more blood flow channels facilitate natural lysis of the thrombus removing the reperfusion device; inserting an expandable thrombus removal device into the microcatheter within the blood vessel and advancing the expandable thrombus removal device to the location of the thrombus, wherein the expandable thrombus removal device comprises a self-expandable removal scaffold having a plurality of interconnected struts that form cells sized and configured to allow thrombus penetration within the cells, thereby facilitating engagement of the thrombus by the removal scaffold; deploying the removal scaffold within a remaining portion of the thrombus by retracting the microcatheter and allowing the removal scaffold to expand, thereby engaging the remaining portion of the thrombus; macerating the thrombus with the removal scaffold by sheathing and unsheathing of the removal scaffold caused by advancement and retraction of the microcatheter, wherein said sheathing and unsheathing causes the removal scaffold to compress and expand, thereby fragmenting, dissolving, or imploding the thrombus; extracting the remaining portion of the thrombus engaged by the removal scaffold from the blood vessel; and removing the thrombus removal device. - View Dependent Claims (21, 22, 23, 24)
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Specification