Compositions and methods for joining non-conjoined lumens
First Claim
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1. A method for joining at least two non-conjoined lumens in a patient, wherein at least one of the lumens has a clamp to arrest the flow of the fluid therein, which method comprises:
- (a) placing a biocompatible sol-gel composition by injection with a hypodermic needle and/or a syringe in a liquid phase or a gel phase in at least a distal portion of the lumen having the clamp, wherein when the sol-gel composition is placed in the lumen in the liquid phase, a phase transition is induced wherein the liquid phase changes to the gel phase, and wherein the gel phase of the sol-gel composition provides structural support to said portion of the lumen;
(b) aligning the lumens;
(c) closing the aligned lumens to form a conduit;
(d) inducing a phase change of the biocompatible sol-gel composition from the gel phase to the liquid phase;
(e) confirming substantial completion of the phase change; and
(f) removing the clamp thereby establishing flow through the conduit.
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Abstract
Disclosed are compositions, methods, and kits for joining together non-conjoined lumens in a patient'"'"'s body including vascular lumens. More particularly, in various aspects, this invention provides compositions, methods, and kits for joining such non-conjoined lumens, including small lumens typically requiring microsurgical technique.
104 Citations
30 Claims
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1. A method for joining at least two non-conjoined lumens in a patient, wherein at least one of the lumens has a clamp to arrest the flow of the fluid therein, which method comprises:
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(a) placing a biocompatible sol-gel composition by injection with a hypodermic needle and/or a syringe in a liquid phase or a gel phase in at least a distal portion of the lumen having the clamp, wherein when the sol-gel composition is placed in the lumen in the liquid phase, a phase transition is induced wherein the liquid phase changes to the gel phase, and wherein the gel phase of the sol-gel composition provides structural support to said portion of the lumen; (b) aligning the lumens; (c) closing the aligned lumens to form a conduit; (d) inducing a phase change of the biocompatible sol-gel composition from the gel phase to the liquid phase; (e) confirming substantial completion of the phase change; and (f) removing the clamp thereby establishing flow through the conduit. - View Dependent Claims (2, 3, 4, 5, 12, 13, 14, 15, 16, 27, 28, 29, 30)
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6. A method for joining at least two non-conjoined lumens in a patient, which method comprises:
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(a) approximating the lumens in a connecting position; (b) providing a biocompatible phase-reversible sol-gel composition in a gel phase in the distal portion of both lumens by injection with a hypodermic needle and/or a syringe; (c) closing the lumens to form a conduit; (d) inducing a phase transition of the sol-gel composition wherein the sol-gel composition changes from the gel phase to a liquid phase; and (e) establishing flow through the conduit. - View Dependent Claims (7, 8, 9, 10, 11)
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17. A method for joining at least two non-conjoined lumens in a patient, wherein at least one of the lumens is clamped to arrest the flow of body fluid therein, which method comprises:
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flushing the distal potion of the clamped lumen with a biocompatible liquid; approximating the lumens in a connecting position, which approximating comprises partially suturing the lumens; providing a biocompatible phase-reversible sol-gel composition in a gel phase in the distal portion of both lumens by injection with a hypodermic needle and/or a syringe; closing the lumens to form a conduit with a biocompatible adhesive; inducing a phase transition of the sol-gel composition wherein the sol-gel composition changes from the gel phase to a liquid phase; confirming substantial completion of the phase transition; and removing the clamps thereby establishing flow through the conduit. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification