Method for treating or inhibiting the formation of adhesions following surgery or injury
First Claim
1. A method for augmenting soft or hard tissue within a mammalian body, comprising:
- (a) providing a first crosslinkable component having m nucleophilic groups, wherein m≧
2 and the m nucleophilic groups are primary amino groups;
(b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2 and m+n≧
5;
(c) applying the first and second crosslinkable components to the tissue; and
(d) allowing the first and second crosslinkable components to crosslink in situ,wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic; and
wherein the first crosslinkable component is C2-C6 hydrocarbyl substituted with amino groups, orwherein the first crosslinkable component is a secondary or tertiary amine NR1R2R3, wherein R1 is hydrogen or an amino-substituted lower alkyl group, and R2 and R3 are amino-substituted lower alkyl groups.
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Abstract
Provided are crosslinked polymer compositions that include a first synthetic polymer containing multiple nucleophilic groups covalently bound to a second synthetic polymer containing multiple electrophilic groups. The first synthetic polymer is preferably a synthetic polypeptide or a polyethylene glycol that has been modified to contain multiple nucleophilic groups, such as primary amino (—NH2) or thiol (—SH) groups. The second synthetic polymer may be a hydrophilic or hydrophobic synthetic polymer, which contains or has been derivatized to contain, two or more electrophilic groups, such as succinimidyl groups. The compositions may further include other components, such as naturally occurring polysaccharides or proteins (such as glycosaminoglycans or collagen) and/or biologically active agents. Also disclosed are methods for using the crosslinked polymer compositions to effect adhesion between a first surface and a second surface; to effect tissue augmentation; to prevent the formation of surgical adhesions; and to coat a surface of a synthetic implant.
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Citations
58 Claims
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1. A method for augmenting soft or hard tissue within a mammalian body, comprising:
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(a) providing a first crosslinkable component having m nucleophilic groups, wherein m≧
2 and the m nucleophilic groups are primary amino groups;(b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2 and m+n≧
5;(c) applying the first and second crosslinkable components to the tissue; and (d) allowing the first and second crosslinkable components to crosslink in situ, wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic; and wherein the first crosslinkable component is C2-C6 hydrocarbyl substituted with amino groups, or wherein the first crosslinkable component is a secondary or tertiary amine NR1R2R3, wherein R1 is hydrogen or an amino-substituted lower alkyl group, and R2 and R3 are amino-substituted lower alkyl groups. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method for treating or inhibiting the formation of adhesions following surgery or injury, comprising:
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(a) providing a first crosslinkable component having m nucleophilic groups, wherein m≧
2 and the m nucleophilic groups are primary amino groups;(b) providing a second crosslinkable component having n electrophilic groups capable of reaction with the m nucleophilic groups to form covalent bonds, wherein n≧
2 and m+n≧
5;(c) applying the first and second crosslinkable components to the tissues comprising, surrounding, and/or adjacent to a wound resulting from surgery or injury; and (d) allowing the first and second crosslinkable components to crosslink in situ, wherein the first and second crosslinkable components are biocompatible, synthetic, and nonimmunogenic; and wherein the first crosslinkable component is C2-C6 hydrocarbyl substituted with amino groups;
orwherein the first crosslinkable component is a secondary or tertiary amine NR1R2R3, wherein R1 is hydrogen or an amino-substituted lower alkyl group, and R2 and R3 are amino-substituted lower alkyl groups. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58)
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Specification