Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof

• US 8,197,837 B2
• Filed: 09/30/2004
• Issued: 06/12/2012
• Est. Priority Date: 03/07/2003
• Status: Active Grant

• Current Assignee: DePuy Mitek Incorporated (Johnson & Johnson)
• Original Assignee: DePuy Mitek Incorporated (Johnson & Johnson)
• Inventors: Jamiolkowski, Dennis D., Brown, Kelly R., Chun, Iksoo, Melican, Mora Carolynne
• Primary Examiner(s): Hartley, Michael G
• Application Number:
  US10/955,370
• Publication Number:
  US 20050113938A1
• Time in Patent Office: 2,812 Days
• Field of Search: 424/422, 424/423
• US Class Current: 424/422
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2/02 Prostheses implantable into the body closure means for urethra or rectum or for artificial body openings therefor A61F2/0004
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61L 2430/34 for soft tissue reconstruction
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 67/04 Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence

Abstract

A biocompatible tissue implant. The tissue implant may be bioabsorbable, consists of a biocompatible polymeric foam. The tissue implant also includes a biocompatible reinforcement member. The polymeric foam and the reinforcement member are soluble in a lyophilizing solvent. The reinforcement may be annealed and/or coated.

Claims

1. A method of repairing damaged tissue, comprising:

providing a biocompatible tissue implant comprising;

a biocompatible polymeric foam, said foam soluble in a lyophilizing solvent;

a biocompatible polymeric reinforcement member, said reinforcement member soluble in the lyophilizing solvent; and

, a polymeric coating having a thickness applied to the reinforcement member, said coating comprising a coating polymer, wherein said coating polymer is substantially insoluble in said lyophilizing solvent; and

, placing the implant in a desired position at a site relative to a tissue injury.

2. The method of claim 1, wherein the implant is placed within a lesion that constitutes the tissue injury.

3. The method of claim 2, wherein the implant is over the lesion.

4. The method of claim 2, wherein the implant is of a size and shape such that it matches a geometry and dimension of the lesion.

5. The method of claim 2, wherein the implant is placed within the lesion in an interference fit.

6. The method of claim 1, wherein the implant is placed adjacent to a lesion that constitutes tear such that the implant reinforces the tissue.

7. The method of claim 1, wherein the implant is wrapped around tissue having a lesion.

8. The method of claim 1, wherein the foamed polymer and the polymeric reinforcement member comprise bioabsorbable polymers.

9. The method of claim 1, wherein the implant is affixed to the site by suturing.

10. The method of claim 1, wherein the implant is affixed to the site by stapling.

11. The method of claim 1, wherein the implant is affixed to the site by using a glue.

12. The method of claim 1, wherein the implant is affixed to the site by using a device selected from the group consisting of suture anchors, tissue tacks, darts, screws, arrows, and combinations thereof.

13. The method of claim 11, wherein the glue is selected from the group consisting of fibrin glues, fibrin clots, platelet rich plasma, platelet poor plasma, blood clots, biologically compatible adhesives, and combinations thereof.

14. The method of claim 1 wherein the tissue comprises soft tissue.

15. The method of claim 1 wherein the coating is bioabsorbable.

16. The method of claim 15 wherein the coating comprises a polymer selected from the group consisting of polydioxanone, and its copolymers with L(−

)-lactide, D(+)-lactide, meso-lactide, trimethylene carbonate, epsilon-caprolactone, or glycolide, or combinations thereof, with the provision that polymerized dioxanone is at least 50 weight percent.

17. The method of claim 15, wherein the coating comprises poly(p-dioxanone).

18. The method of claim 1, wherein the thickness of the coating is greater than about 1.0 mil.

19. The method of claim 1, wherein the lyophilizing solvent is selected from the group consisting of p(dioxane) and trioxane.

20. The method of claim 19, wherein the lyophilizing solvent comprises p(dioxane).