Composition and method for treating diabetes and metabolic disorders

• US 8,198,319 B2
• Filed: 01/27/2011
• Issued: 06/12/2012
• Est. Priority Date: 03/19/2007
• Status: Active Grant

• Current Assignee: ATM Metabolics, LLC
• Original Assignee: ATM Metabolics, LLC
• Inventors: Ahrens, Milton Joseph, Thompson, Daryl Lee
• Primary Examiner(s): Vivlemore, Tracy
• Assistant Examiner(s): BERRIOS, JENNIFER A
• Application Number:
  US13/014,798
• Publication Number:
  US 20110118345A1
• Time in Patent Office: 502 Days
• Field of Search: None
• US Class Current: 514/456
• CPC Class Codes: A23L 33/105 Plant extracts, their artificial duplicates or their derivatives
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/30 Foods, ingredients or supplements having a functional effect on health
• CPC Class Codes: A23V 2200/328 having effect on glycaemic control and diabetes
• CPC Class Codes: A23V 2250/21 Plant extracts
• CPC Class Codes: A23V 2250/21168 Quercetin
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/192 having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid cannabinoids A61K31/658
• CPC Class Codes: A61K 31/216 of acids having aromatic rings, e.g. benactizyne, clofibrate
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 31/353 3,4-Dihydrobenzopyrans, e.g. chroman, catechin
• CPC Class Codes: A61P 3/00 Drugs for disorders of the metabolism of the blood or the extracellular fluid A61P7/00
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A composition and method for treating diabetes and metabolic disorders, and for achieving weight loss in a subject comprising a combination of naturally occurring compounds is provided.

Claims

1. A method of treating diabetes or obesity in a subject, the method comprising administering to the subject a composition consisting of therapeutically effective amounts of quercetin, myricetin and chlorogenic acid.

2. The method of claim 1 wherein the composition comprises about 50 mg to about 500 mg quercetin;

about 50 to about 500 mg myricetin and about 25 to about 150 mg chlorogenic acid.

3. The method of claim 1 wherein the composition comprises about 100 mg to about 200 mg quercetin;

about 100 to about 200 mg myricetin and about 30 to about 75 mg chlorogenic acid.

4. The method of claim 1 wherein the ratio of chlorogenic acid to quercetin to myricetin is about 1:

3;

3.

5. The method of claim 1 wherein the subject is administered at least 750 mg of the composition daily.

6. A method of lowering the glycemic index of a carbohydrate-containing foodstuff comprising adding to the foodstuff an effective amount of a composition consisting of quercetin, myricetin and chlorogenic acid, wherein said composition is added to reduce the glycemic index of the carbohydrate-containing foodstuff.

7. The method of claim 6 wherein the foodstuff is a beverage and the composition is added to the beverage in an amount of about 0.5 to about 1.5 mg per ml of beverage.

8. The method of claim 6 wherein the foodstuff is baked goods and the composition is added to the baked goods in an amount of about 2.5 mg to about 10 mg per gram of baked goods.

9. The method of claim 6 wherein the composition comprises a ratio of chlorogenic acid to quercetin to myricetin of about 1:

3;

3 by weight.