Hypoglycemic activity of osthole

• US 8,198,320 B2
• Filed: 12/31/2008
• Issued: 06/12/2012
• Est. Priority Date: 12/31/2008
• Status: Expired due to Fees

• Current Assignee: Taipei Medical University WAN Fan Hospital (Government of The Republic of China)
• Original Assignee: Taipei Medical University WAN Fan Hospital (Government of The Republic of China)
• Inventors: Liang, Yu-Chih, Liu, Der-Zen, Hung, Ling-Fang, Lin, Pei-Jung, Chen, Nai-Qi, Chen, Yu-Chien
• Primary Examiner(s): Weddington, Kevin E
• Application Number:
  US12/347,429
• Publication Number:
  US 20100168224A1
• Time in Patent Office: 1,259 Days
• Field of Search: 514/457, 514/635, 424/725
• US Class Current: 514/457
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61P 3/08 for glucose homeostasis pancreatic hormones A61P5/48

Abstract

The present invention relates to a method for controlling blood glucose level and a method for the prophylaxis or treatment of diabetes mellitus and/or its complications. The present invention further relates to an anti-diabetic formulation for controlling blood glucose level and/or for the prophylaxis or treatment of diabetes mellitus and/or its complications.

Claims

1. A method for the treatment of type II diabetes mellitus and/or its complications comprising administering a therapeutically effective amount of osthole or a pharmaceutically acceptable derivative thereof to a subject in need thereof, wherein osthole is chemically synthesized or purified at a purity of at least 95%.

2. The method according to claim 1, wherein the therapeutically effective amount is about 10 to about 200 mg/kg/day.

3. The method according to claim 1, wherein the therapeutically effective amount is about 50 mg/kg/day.

4. The method according to claim 1, wherein the osthole or pharmaceutically acceptable derivative thereof is administered to the subject parenterally or orally.

5. The method according to claim 1, wherein the subject is a mammal.

6. The method according to claim 5, wherein the mammal is a human.

7. The method according to claim 1, further comprising administering a second agent effective for the treatment of diabetes mellitus.

8. The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium plant.

9. The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium monnieri (L.) Cuss.

10. The method according to claim 1, wherein osthole or a pharmaceutically acceptable derivative thereof is obtained from Cnidium fruit.